Winner by points? - LDL cholesterol as a target for therapeutic intervention

TietgeU.J.F.

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Winner by points? - LDL cholesterol as a target for therapeutic intervention

机译：获胜点？ -LDL胆固醇作为治疗干预的目标

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Observational studies identified two major risk factors for atherosclerotic cardiovascular disease that compete as therapeutic intervention targets, high levels of LDL cholesterol (LDL-C) and low levels of HDL cholesterol (HDL-C) [1]. LDL particles represent the forward pathway of cholesterol towards atherosclerotic lesions and mostly carry cholesterol, thus LDL-C measurements likely truly reflect function. HDL are a diverse class of particles carrying a variety of lipid and protein cargo translating into various potentially atheroprotective functionalities, among these reverse cholesterol transport [2]. It is currently unclear, to what extent HDL-C measurements authentically reflect HDL function.

机译：观察性研究确定了动脉粥样硬化性心血管疾病的两个主要危险因素，它们可以作为治疗干预目标竞争：高水平的LDL胆固醇（LDL-C）和低水平的HDL胆固醇（HDL-C）[1]。 LDL颗粒代表胆固醇向动脉粥样硬化病变的前进途径，并且主要携带胆固醇，因此LDL-C测量值可能确实反映了功能。 HDL是一类携带多种脂质和蛋白质的颗粒，在这些逆向胆固醇转运中，这些脂质和蛋白质转变成各种潜在的抗动脉粥样硬化功能[2]。目前尚不清楚，HDL-C测量在多大程度上真实地反映了HDL功能。

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《Current opinion in lipidology》 |2013年第3期|共2页
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TietgeU.J.F.;
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专利

1. Winner by points? - LDL cholesterol as a target for therapeutic intervention [J] . TietgeU.J.F. Current opinion in lipidology . 2013,第3期

机译：获胜点？ -LDL胆固醇作为治疗干预的目标
2. Implications of the obesity epidemic for lipid-lowering therapy: Non-HDL cholesterol should replace LDL cholesterol as the primary therapeutic target [J] . Michel R Hoenig Vascular Health and Risk Management . 2008,第1期

机译：肥胖症流行病对降脂治疗的影响：非HDL胆固醇应取代LDL胆固醇作为主要治疗目标
3. Lower frequency of non-target lesion intervention in post-successful percutaneous coronary intervention patients with an LDL to HDL cholesterol ratio below 1.5. [J] . Fukuda Y, Miura S, Tsuchiya Y, International Journal of Cardiology . 2011,第1期

机译：LDL与HDL胆固醇比低于1.5的成功经皮冠状动脉介入治疗后患者非目标病变干预的频率较低。
4. The Effect of Soymilk Consumption Toward Reduction Levels of Total Cholesterol and LDL Cholesterol on Menopause Women [C] . Meti Kusmiati, Rianti Nurpalah, Amalia Putri Elganita, Bakti Tunas Husada-Health Science International Conference . 2020

机译：豆浆机消费对绝经胆固醇总胆固醇和LDL胆固醇减少水平的影响
5. Diagnosis, Rupture Risk Evaluation and Therapeutic Intervention of Abdominal Aortic Aneurysms Using Targeted Nanoparticles [D] . Wang, Xiaoying. 2020

机译：使用靶向纳米粒子的诊断，破裂风险评估和腹主动脉瘤治疗干预
6. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates [O] . Maria Frank-Kamenetsky, Aldo Grefhorst, Norma N. Anderson, 2008

机译：靶向PCSK9的治疗性RNAi急剧降低了啮齿动物的血浆胆固醇和非人类灵长类动物的LDL胆固醇
7. Secondary prevention in CAD: A significant correlation between LDL-cholesterol (LDL-C) achieved therapeutically and extent of progression reduction claims for LDL-C target levels < 100 mg/dl [O] . Bestehom H.P., Rensing U.F.E., Roskamm H., 1996

机译：CAD的二级预防：在治疗上达到的LDL-胆固醇（LDL-C）与LDL-C目标水平<100 mg / dl的进展减少程度之间存在显着相关性

Winner by points? - LDL cholesterol as a target for therapeutic intervention

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