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首页> 外文期刊>Current opinion in lipidology >What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?
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What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?

机译：对胰岛素敏感和耐药的严重肥胖人群的脂肪组织有何区别？

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PURPOSE OF REVIEW: Despite a strong correlation between obesity and insulin resistance, 25% of severely obese (BMI >40) individuals are insulin sensitive. In this review, we will examine the factors in adipose tissue that distinguish the two groups, as well as reasons for believing the insulin-sensitive group will be less disease prone. RECENT FINDINGS: Obesity has been linked to the metabolic syndrome with an increase in visceral (intra-abdominal) compared to subcutaneous fat. Recent studies in which adipose tissue of insulin-sensitive and insulin-resistant patients with severe obesity were compared indicate that the insulin-resistant group is also distinguished by increases in oxidative stress and decreases in AMP-activated protein kinase (AMPK) activity. In contrast, changes in the expression of genes for SIRT1, inflammatory cytokines, mitochondrial biogenesis and function, and the two ??-isoforms of AMPK showed more depot variation. Studies of how these and other changes in adipose tissue respond to bariatric surgery are still in their infancy. SUMMARY: Available data suggest that increases in oxidative stress, decreases in AMPK activity and SIRT1 gene expression, depot-specific changes in inflammatory, mitochondrial and other genes distinguish adipose tissue of insulin resistant from insulin-sensitive individuals with severe obesity. ? 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
机译：审查目的：尽管肥胖与胰岛素抵抗之间有很强的相关性，但25％的严重肥胖（BMI> 40）个体对胰岛素敏感。在这篇综述中，我们将检查脂肪组织中区分两组的因素，以及认为胰岛素敏感性组患病率较低的原因。最近的发现：与皮下脂肪相比，肥胖与内脏（腹腔内）增加的代谢综合征有关。比较胰岛素敏感性和胰岛素抵抗性严重肥胖患者的脂肪组织的最新研究表明，胰岛素抵抗性组还具有氧化应激增加和AMP活化蛋白激酶（AMPK）活性降低的特点。相反，SIRT1基因的表达，炎性细胞因子，线粒体的生物发生和功能的变化以及AMPK的两种Δβ同工型显示出更大的贮库变异。脂肪组织中这些和其他变化如何响应减肥手术的研究仍处于起步阶段。摘要：现有数据表明，氧化应激的增加，AMPK活性和SIRT1基因表达的降低，炎症，线粒体和其他基因的贮库特异性变化将胰岛素抵抗的脂肪组织与严重肥胖的胰岛素敏感性患者区分开。 ？ 2013威科集团健康|利平科特·威廉姆斯和威尔金斯。

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