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Main findings from the prospective Cardiovascular Risk in Young Finns Study

机译：年轻芬兰人的前瞻性心血管风险研究的主要发现

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PURPOSE OF REVIEW: To provide a comprehensive overview on the main findings from the Cardiovascular Risk in Young Finns Study. This prospective multicenter study initiated in 1980 (N=3596, baseline age 3-18 years) has followed up study participants over 30 years to investigate childhood risk factors for cardiometabolic outcomes in adulthood. RECENT FINDINGS: Childhood BMI, socioeconomic status, parental risk factor status, as well as genetic polymorphisms are independent predictors of adult obesity, hypertension, and dyslipidemia. Results from the Young Finns Study and other follow-up studies have shown that conventional childhood risk factors, such as dyslipidemia, obesity, elevated blood pressure and smoking, are predictive of subclinical atherosclerosis in young adults. Recent findings suggest that childhood lifestyle (diet, physical activity) is associated with subclinical atherosclerosis and its progression in adulthood. Concerning the timing of risk factor measurements, they seem to be predictive of adult atherosclerosis from the age of 9 onwards. From a clinical point of view, a recent observation suggesting that the adverse cardiometabolic effects of childhood overweight/obesity are reversed among those who become nonobese adults, provides optimism during the days of obesity epidemic. SUMMARY: Current data suggest that childhood risk factors are associated with higher risk of subclinical atherosclerosis in adulthood. Future studies among aging cohorts followed since childhood will provide data on their influence on clinical cardiovascular outcomes. ? 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
机译：审查目的：提供有关年轻芬兰人心血管风险研究的主要结果的全面概述。这项始于1980年的前瞻性多中心研究（N = 3596，基线年龄3-18岁）对研究参与者进行了30多年的随访，以调查儿童期成年后心脏代谢结果的危险因素。最近的发现：儿童的BMI，社会经济状况，父母的危险因素状况以及遗传多态性是成人肥胖，高血压和血脂异常的独立预测因子。 Young Finns研究和其他后续研究的结果表明，常规的儿童期危险因素，例如血脂异常，肥胖，血压升高和吸烟，可预测年轻人的亚临床动脉粥样硬化。最近的发现表明，儿童时期的生活方式（饮食，体育锻炼）与亚临床动脉粥样硬化及其在成年期的进展有关。关于危险因素的测量时间，他们似乎可以预测从9岁开始的成人动脉粥样硬化。从临床角度来看，最近的一项观察表明，儿童肥胖和非肥胖成年人的童年超重/肥胖对心脏的不良代谢作用得到了逆转，使人们在肥胖流行期间感到乐观。摘要：目前的数据表明，儿童期的危险因素与成年期亚临床动脉粥样硬化的较高风险有关。自孩提时代起就对年龄较大的人群进行了进一步的研究，将提供有关其对临床心血管结局影响的数据。 ？ 2013威科集团健康|利平科特·威廉姆斯和威尔金斯。

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