• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in lipidology >HDL quality or cholesterol cargo: What really matters - Spotlight on sphingosine-1-phosphate-rich HDL
【24h】

HDL quality or cholesterol cargo: What really matters - Spotlight on sphingosine-1-phosphate-rich HDL

机译：HDL质量或胆固醇含量：真正重要的是-富含鞘氨醇-1-磷酸的HDL的关注点

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose of review: The absolute level of HDL cholesterol (HDL-C) may not be the only criterion contributing to their antiatherothrombotic effects. This review focuses on evidence in support of the concept that HDL-bound sphingosine-1-phosphate (S1P) plays a role in different HDL atheroprotective properties and may represent a potential target for therapeutic interventions. Recent findings: Recent large randomized clinical trials testing the hypothesis of raising HDL-C with niacin and dalcetrapib in statin-treated patients failed to improve cardiovascular outcomes. Emerging evidence suggests that many of the cardioprotective functions of HDL, such as vasodilation, angiogenesis and endothelial barrier function, protection against ischemia/reperfusion injury, and inhibition of atherosclerosis, may be attributable to its S1P cargo. HDL-associated S1P may represent a future therapeutic target. Summary: HDL functionality is affected by its composition and there is evidence to suggest S1P plays a role in some of HDL's functions and atheroprotective properties.
机译：审查目的：HDL胆固醇（HDL-C）的绝对水平可能不是促进其抗动脉粥样硬化形成作用的唯一标准。这篇综述着重于证据支持HDL结合的1-磷酸鞘氨醇（S1P）在不同的HDL动脉粥样硬化防护特性中的作用，并可能代表治疗干预的潜在目标。最新发现：最近进行的大型随机临床试验测试了在他汀类药物治疗的患者中使用烟酸和达塞曲普升高HDL-C的假设未能改善心血管结局。新兴证据表明，HDL的许多心脏保护功能，例如血管舒张，血管生成和内皮屏障功能，针对缺血/再灌注损伤的保护作用以及对动脉粥样硬化的抑制作用，都可归因于其S1P货物。 HDL相关的S1P可能代表了未来的治疗目标。简介：HDL功能受其组成影响，并且有证据表明S1P在HDL的某些功能和抗动脉粥样硬化特性中起作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号