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Atherosclerosis: Cell biology and lipoproteins

机译:动脉粥样硬化:细胞生物学和脂蛋白

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Atherosclerosis-based cardiovascular diseases have a devastating impact on public health. Therefore, exploring molecular mechanisms of atherosclerosis is an important focus for development of effective therapeutic strategies. This Bimonthly Update summarizes recent publications that have provided new insights into leukocyte-related mechanisms in the development of atherosclerosis.Macrophage accumulation is a dominant feature of early atherosclerosis and could be due to changes in recruitment, emigration, proliferation, or death. To gain insights into mechanisms provoking macrophage emigration, van Gils et al. investigated netrin-1, a protein involved in chemorepulsion and chemoattraction of axons. Netrin-1 was present in macrophages of atherosclerotic lesions.
机译:基于动脉粥样硬化的心血管疾病对公共健康具有毁灭性影响。因此,探索动脉粥样硬化的分子机制是发展有效治疗策略的重要重点。本双月更新总结了最近的出版物,这些出版物为动脉粥样硬化发展中白细胞相关的机制提供了新的见解。巨噬细胞积累是早期动脉粥样硬化的主要特征,可能是由于募集,移民,增殖或死亡的变化所致。为了深入了解引起巨噬细胞迁移的机制,van Gils等人。研究了netrin-1,一种参与轴突化学趋化和化学引诱的蛋白质。 Netrin-1存在于动脉粥样硬化病变的巨噬细胞中。

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