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Novel B-cell subsets in atherosclerosis

机译：动脉粥样硬化中的新型B细胞亚群

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Purpose of reviewThe number of deaths associated with cardiovascular disease remains high, despite great advances in treating the associated high levels of cholesterol. The main underlying pathology of cardiovascular disease is atherosclerosis, which is recognized as a chronic autoimmune-like inflammatory disease. Hence, there is a pressing need to shed light on the immune pathways associated with atherosclerosis. B cells have long been thought to have a general protective effect in atherosclerosis. However, findings in the last decade have challenged this paradigm, showing that it is crucial to differentiate between the various B-cell subsets when assessing their role/effect on atherosclerosis.Recent findingsIt has become increasingly recognized lately that B cells can have significant effects on the immune system independent of antibody production. The understanding that B cells form a major source of cytokines and can directly influence T-cell responses via surface markers, have led to the identification of novel B-cell subsets. These subsets are important modulators of autoimmune disorders but have not yet been fully investigated in atherosclerosis.SummaryHere we review the current known roles of B-cell subsets and the putative effects of recently identified B cells on atherosclerosis.
机译：回顾的目的尽管在治疗相关高胆固醇水平方面取得了重大进展，但与心血管疾病相关的死亡人数仍然很高。心血管疾病的主要潜在病理是动脉粥样硬化，它被认为是一种慢性自身免疫性炎性疾病。因此，迫切需要阐明与动脉粥样硬化有关的免疫途径。长期以来，人们一直认为B细胞在动脉粥样硬化中具有一般的保护作用。然而，近十年来的发现挑战了这一范例，表明在评估各种B细胞亚群对动脉粥样硬化的作用/效应时区分这些至关重要。免疫系统独立于抗体的产生。 B细胞是细胞因子的主要来源，并且可以通过表面标记直接影响T细胞反应，这一认识已导致鉴定出新颖的B细胞亚群。这些亚群是自身免疫性疾病的重要调节因子，但尚未在动脉粥样硬化中得到充分研究。总结在这里，我们回顾了B细胞亚群的当前已知作用以及最近发现的B细胞对动脉粥样硬化的假定作用。

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