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首页> 外文期刊>Current opinion in gastroenterology >Corpus predominant gastritis: what does it mean?
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Corpus predominant gastritis: what does it mean?

机译：语料库优势胃炎：是什么意思？

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PURPOSE OF REVIEW: To summarize this year's relevant literature on the causes and mechanisms of autoimmune gastritis. RECENT FINDINGS: It is increasingly recognized that parietal cell antibodies, previously assumed exclusive to autoimmune gastritis, are associated with Helicobacter pylori infection. Successful H. pylori eradication with antibiotic treatment decreases antiparietal cell antibodies. Interestingly, vitamin B(12) deficiency, previously associated with autoimmune gastritis, is increasingly described in the elderly, irrespective of H. pylori status. Autoimmune gastritis that mostly affects patients of Scandinavian descent, was reported this year from China, and corpus predominant gastritis (autoimmune associated) was reported from Japan. It is difficult to evaluate the role played by genetics, increased use of proton pump inhibitors, and H. pylori infection, as current patient work-up does not regularly include screening for parietal cell and intrinsic-factor antibodies. As these clinicopathologic changes are seen in both H. pylori-positive patients, and in H. pylori-naive patients, the debate continues for mechanisms involved in H. pylori-naive patients. SUMMARY: The clinical features commonly associated with autoimmune gastritis are increasingly seen in the elderly, irrespective of H. pylori status. Though some patients are genetically predisposed, long-term proton pump inhibitor use increases the prevalence of clinicopathologic features irrespective of genetic tendency.
机译：审查目的：总结今年有关自身免疫性胃炎的病因和机制的相关文献。最近的发现：越来越多的人认识到，壁细胞抗体以前被认为是自身免疫性胃炎所独有的，它与幽门螺杆菌感染有关。抗生素治疗成功根除幽门螺杆菌会降低抗壁细胞抗体。有趣的是，与幽门螺杆菌状态无关的老年人中，以前与自身免疫性胃炎相关的维生素B（12）缺乏症越来越多。今年，中国报道了主要影响斯堪的纳维亚血统患者的自身免疫性胃炎，日本报道了主体胃炎（自身免疫相关）。很难评估遗传因素，质子泵抑制剂的使用增加以及幽门螺杆菌感染的作用，因为当前的患者检查不定期包括筛查壁细胞和内在因子抗体。由于在幽门螺杆菌阳性患者和未感染幽门螺杆菌的患者中均可见到这些临床病理变化，因此有关未发生幽门螺杆菌的患者所涉及机制的争论仍在继续。摘要：不论幽门螺杆菌状态如何，老年人中常见与自身免疫性胃炎相关的临床特征越来越多。尽管有些患者具有遗传易感性，但长期使用质子泵抑制剂会增加临床病理特征的发生率，而与遗传趋势无关。

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