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首页> 外文期刊>Current opinion in gastroenterology >Serum and bile biomarkers for cholangiocarcinoma.
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Serum and bile biomarkers for cholangiocarcinoma.

机译：胆管癌的血清和胆汁生物标志物。

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PURPOSE OF REVIEW: To discuss recent studies proposing new markers in serum or bile for the diagnosis and prognosis of cholangiocarcinoma (CCA), which could help in the differential diagnosis between malignant and benign biliary disorders or for the surveillance of disorders at risk, including primitive sclerosing cholangitis. RECENT FINDINGS: In the last few years, efforts have been made to identify biomarkers with adequate diagnostic accuracy for CCA in serum or biological fluid. Studies have been focused on cytokines, growth factors or enzymes produced and secreted by CCA cells as well as on the proteomic analysis of serum and bile. SUMMARY: The serum levels of interleukin 6, trypsinogen, mucin-5AC, soluble fragment of cytokeratin 19 and the platelet-lymphocyte ratio have been recently shown to help in the diagnosis of CCA with, in some cases, a prognostic value. As far as bile is concerned, the ratio of pancreatic elastase/amylase, mucin-4, minichromosome maintenance replication protein and insulin-like growth factor 1 have been explored, with the insulin-like growth factor 1 biliary concentration capable of completely discriminating CCA from benign biliary disorders and pancreatic cancer. We have also discussed advances in the proteomic of serum and bile, which seem promising in identifying new markers for CCA.
机译：审查的目的：讨论最近提出的血清或胆汁中新标记物用于胆管癌（CCA）的诊断和预后的研究，这可能有助于恶性和良性胆道疾病的鉴别诊断或监测包括原发性在内的高风险疾病硬化性胆管炎。最近的发现：在过去的几年中，已经做出努力来鉴定对血清或生物体液中的CCA具有足够诊断准确性的生物标志物。研究集中于CCA细胞产生和分泌的细胞因子，生长因子或酶，以及血清和胆汁的蛋白质组学分析。摘要：最近显示，血清白介素6，胰蛋白酶原，粘蛋白5AC，细胞角蛋白19的可溶性片段和血小板-淋巴细胞比率有助于诊断CCA，在某些情况下具有预后价值。就胆汁而言，已经探索了胰腺弹性蛋白酶/淀粉酶，粘蛋白4，微染色体维持复制蛋白和胰岛素样生长因子1的比率，其中胰岛素样生长因子1的胆汁浓度能够完全区分CCA与良性胆道疾病和胰腺癌。我们还讨论了血清蛋白和胆汁蛋白质组学方面的进展，这些进展在鉴定CCA的新标志物方面似乎很有希望。

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