Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial

Hardy Jo; Baggott Christina; Fingleton James; Reddel Helen K.; Hancox Robert J.; Harwood Matire; Corin Andrew; Sparks Jenny; Hall Daniela; Sabbagh Donah; Mane Saras; Vohlidkova Alexandra; Martindale John; Williams Mathew; Shirtcliffe Philippa; Holliday Mark; Weatherall Mark; Beasley Richard

首页> 外文期刊>The Lancet >Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial

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Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial

机译：Budesonide-Formoterol Reliever疗法与维护培养蛋白质加上特布尔胺救济疗法加入患有轻度至中度哮喘（实用）的成人（实用）：52周，开放式标签，多方形，优势，随机对照试验

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Background In adults with mild asthma, a combination of an inhaled corticosteroid with a fast-onset long-acting beta-agonist (LABA) used as reliever monotherapy reduces severe exacerbations compared with short-acting beta-agonist (SABA) reliever therapy. We investigated the efficacy of combination budesonide-formoterol reliever therapy compared with maintenance budesonide plus as-needed terbutaline.

机译：背景技术在具有轻度哮喘的成人中，用作释放单疗法的快速发作长效β-激动剂（Laba）的吸入皮质类固醇的组合降低了与短作用β-激动剂（SABA）释放治疗相比的严重加剧。我们调查了组合蛋白质 - 蛋白质 - 蛋白质溶剂治疗的疗效与维持培养蛋白剂加上依赖的特贝林胺相比。

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《The Lancet》 |2019年第10202期|共10页
作者
Hardy Jo; Baggott Christina; Fingleton James; Reddel Helen K.; Hancox Robert J.; Harwood Matire; Corin Andrew; Sparks Jenny; Hall Daniela; Sabbagh Donah; Mane Saras; Vohlidkova Alexandra; Martindale John; Williams Mathew; Shirtcliffe Philippa; Holliday Mark; Weatherall Mark; Beasley Richard;
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Med Res Inst New Zealand Wellington 6242 New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Univ Sydney Woolcock Inst Med Res Sydney NSW Australia;

Waikato Hosp Hamilton New Zealand;

Univ Auckland Auckland New Zealand;

Clin Horizons Tauranga New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

Univ Otago Wellington Wellington New Zealand;

Med Res Inst New Zealand Wellington 6242 New Zealand;

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正文语种 eng
中图分类医药、卫生;
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1. Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial (vol 394, pg 919, 2019) [J] . Hardy J., Baggott C., Fingleton J. The Lancet . 2020,第10234期

机译：Budesonide-formoterol refiever治疗与维护Budesonide加上特布尔氨酸救济疗法加上患有轻度至中度哮喘的成人（实用）：52周，开放式标签，多方形，优势，随机对照试验（Vol 394，PG 919,2019）
2. Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial [J] . Hardy Jo, Baggott Christina, Fingleton James, The Lancet . 2019,第10202期

机译：Budesonide-Formoterol Reliever疗法与维护培养蛋白质加上特布尔胺救济疗法加入患有轻度至中度哮喘（实用）的成人（实用）：52周，开放式标签，多方形，优势，随机对照试验
3. Budesonide/formoterol for maintenance and reliever therapy of asthma: a meta analysis of randomised controlled trials. [J] . Edwards SJ, von Maltzahn R, Naya IP, International journal of clinical practice . 2010,第5期

机译：布地奈德/福莫特罗用于维持和缓解哮喘的治疗：一项随机对照试验的荟萃分析。
4. Effectiveness of various regimens of maintaining anti-inflammatory therapy in mild to moderate asthmatic children: results of the prospective multicenter randomized trial [C] . Tereshchenko S., Smirnova S., Novitckii I., World Asthma, Allergy COPD Forum . 2014

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5. Acupuncture therapy as adjunctive treatment in adult patients with mild to moderate persistent asthma [D] . Ansari, Zenas 2016

机译：针灸疗法作为成人轻度至中度持续性哮喘的辅助治疗
6. The effect of budesonide/formoterol maintenance and reliever therapy on the risk of severe asthma exacerbations following episodes of high reliever use: an exploratory analysis of two randomised controlled studies with comparisons to standard therapy [O] . Roland Buhl, Piotr Kuna, Matthew J Peters, 2012

机译：布地奈德/福莫特罗维持和缓解疗法对高缓解剂使用后严重哮喘加重风险的影响：与标准疗法比较的两项随机对照研究的探索性分析
7. Efficacy and safety of maintenance and reliever combination budesonide/formoterol therapy in asthma patients at risk of severe exacerbations: a randomised controlled trial [O] . Patel Mitesh Dilipkumar Kantilal 100

机译：维生素和缓解剂联合布地奈德/福莫特罗治疗有严重急性发作风险的哮喘患者的疗效和安全性：随机对照试验

Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial

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