Drug-induced liver disease

David Novak; James H. Lewis

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Drug-induced liver disease

机译：药物性肝病

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The year 2002 saw a warning from the US Food and Drug Administration not to use the diet agent, Lipokinetix, and brought to light a few new agents as potential hepatotoxins. Numerous other reports confirmed the hepatotoxicity of several previously described agents. Refinements in causality assessment remain an important aspect in defining drug-induced liver disease and proposed new upper limits of normal for alanine aminotransferase that are lower than most laboratories currently report may require rethinking our definition of "normal liver function tests." Chronic viral hepatitis B and C remain important risk factors for antiretroviral-induced liver injury in patients co-infected with the human immunodeficiency virus and in patients receiving antituberculosis therapy. Acetaminophen retains its status as the most common cause of acute drug-induced liver failure in the United States and in many other countries. Several papers addressed the issue of accidental versus intentional overdoses, the role of alcohol consumption as a risk factor, and newer aspects of treating and preventing acetaminophen injury to the liver. Finally, the use of potentially hepatotoxic medications in patients with underlying liver disease continues to be a controversial topic and a rational approach to the use of such drugs in this setting is provided.

机译：2002年，美国食品和药物管理局警告不要使用减肥药Lipokinetix，并发现了一些新的药物作为潜在的肝毒素。许多其他报告证实了几种先前描述的药物的肝毒性。因果关系评估的细化仍然是定义药物诱发的肝病的重要方面，并且提议的丙氨酸转氨酶正常值的新上限低于目前大多数实验室的报告，可能需要重新考虑我们对“正常肝功能测试”的定义。乙型和丙型慢性病毒性肝炎仍然是感染人类免疫缺陷病毒的患者和接受抗结核治疗的患者抗逆转录病毒引起的肝损伤的重要危险因素。在美国和许多其他国家/地区，对乙酰氨基酚仍是急性药物性肝衰竭的最常见原因。几篇论文讨论了意外和故意过量使用，饮酒作为危险因素的作用以及治疗和预防对乙酰氨基酚对肝脏的损伤等新问题。最后，在潜在的肝病患者中使用潜在的肝毒性药物仍然是一个有争议的话题，并且提供了在这种情况下使用此类药物的合理方法。

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《Current opinion in gastroenterology》 |2003年第3期|共13页
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David Novak; James H. Lewis;
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中图分类消化系及腹部疾病;
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1. Patients With Chronic Liver Disease Suggestive of Nonalcoholic Fatty Liver Disease May Be at Higher Risk for Drug-Induced Liver Injury [J] . Lammert Craig, Imler Timothy, Teal Evgenia, Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association . 2019,第13期

机译：慢性肝病患者暗示非酒精性脂肪肝病的患者可能是药物诱导的肝损伤的风险较高
2. Drug-Induced Liver Disease and Drug Use Considerations in Liver Disease [J] . Jiwon W. Kim, Paula V. Phongsamran Journal of pharmacy practice . 2009,第3期

机译：药物引起的肝病和肝病中的药物使用注意事项
3. Expression patterns and action analysis of genes associated with drug-induced liver diseases during rat liver regeneration [J] . Qian-Ji Ning, Shao-Wei Qin, Cun-Shuan Xu World Journal of Gastroenterology . 2006,第43期

机译：大鼠肝再生过程中药物性肝病相关基因的表达模式及作用分析
4. Computer-Aided Assessment of Drug-Induced Lung Disease Plausibility [C] . Brigitte Seroussi, Jacques Bouaud, Hugette Liote, Conference on Artificial Intelligence in Medicine(AIME 2007); 20070707-11; Amsterdam(NL) . 2007

机译：药物诱导的肺部疾病真实性的计算机辅助评估
5. Involvement of Th17 Pathway in Adverse Drug Reactions: Mechanistic Investigation of Drug-Induced Autoimmunity and Drug-induced Liver Injury. [D] . Zhu, Ervin Xu. 2012

机译：Th17途径参与药物不良反应：药物诱发的自身免疫和药物诱发的肝损伤的机制研究。
6. Expression patterns and action analysis of genes associated with drug-induced liver diseases during rat liver regeneration [O] . Qian-Ji Ning, Shao-Wei Qin, Cun-Shuan Xu 2006

机译：大鼠肝再生过程中药物性肝病相关基因的表达模式及作用分析
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Drug-induced liver disease

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