Real-time continuous glucose monitoring in adults with type 1 diabetes and impaired hypoglycaemia awareness or severe hypoglycaemia treated with multiple daily insulin injections (HypoDE): a multicentre, randomised controlled trial

Heinemann Lutz; Freckmann Guido; Ehrmann Dominic; Faber-Heinemann Gabriele; Guerra Stefania; Waldenmaier Delia; Hermanns Norbert

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Real-time continuous glucose monitoring in adults with type 1 diabetes and impaired hypoglycaemia awareness or severe hypoglycaemia treated with multiple daily insulin injections (HypoDE): a multicentre, randomised controlled trial

机译：1型糖尿病患者的成人实时连续葡萄糖监测和用多种日常胰岛素注射治疗的低血糖意识或严重低血糖受损（Hypode）：多期，随机对照试验

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Background The effectiveness of real-time continuous glucose monitoring (rtCGM) in avoidance of hypoglycaemia among high-risk individuals with type 1 diabetes treated with multiple daily insulin injections (MDI) is unknown. We aimed to ascertain whether the incidence and severity of hypoglycaemia can be reduced through use of rtCGM in these individuals.

机译：背景技术实时连续葡萄糖监测（RTCGM）在避免用多种每日胰岛素注射（MDI）处理的高风险患有1型糖尿病（MDI）的高危个体中低血糖中的低血糖血症的有效性是未知的。我们旨在通过在这些个体中使用RTCGM来确定低血糖的发病率和严重程度是否可以减少。

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来源
《The Lancet》 |2018年第10128期|共11页
作者
Heinemann Lutz; Freckmann Guido; Ehrmann Dominic; Faber-Heinemann Gabriele; Guerra Stefania; Waldenmaier Delia; Hermanns Norbert;
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作者单位

Sci Consulting Diabet GmbH Dusseldorf Germany;

Univ Ulm IDT Forschungs &

Entwicklungsgesell mbH Ulm Germany;

Diabet Acad Mergentheim FIDAM Diabet Res Inst D-97980 Bad Mergentheim Germany;

Sci Consulting Diabet GmbH Dusseldorf Germany;

Dexcom Inc San Diego CA USA;

Univ Ulm IDT Forschungs &

Entwicklungsgesell mbH Ulm Germany;

Diabet Acad Mergentheim FIDAM Diabet Res Inst D-97980 Bad Mergentheim Germany;

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正文语种 eng
中图分类医药、卫生;
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1. Real-time continuous glucose monitoring in adults with type 1 diabetes and impaired hypoglycaemia awareness or severe hypoglycaemia treated with multiple daily insulin injections (HypoDE): a multicentre, randomised controlled trial [J] . Heinemann Lutz, Freckmann Guido, Ehrmann Dominic, The Lancet . 2018,第10128期

机译：1型糖尿病患者的成人实时连续葡萄糖监测和用多种日常胰岛素注射治疗的低血糖意识或严重低血糖受损（Hypode）：多期，随机对照试验
2. Continuous glucose monitoring for patients with type 1 diabetes and impaired awareness of hypoglycaemia (IN CONTROL): a randomised, open-label, crossover trial [J] . van Beers Cornelis A. J., DeVries J. Hans, Kleijer Susanne J., The lancet. Diabetes & endocrinology. . 2016,第11期

机译：持续监测1型糖尿病和低血糖意识受损的葡萄糖（IN CONTROL）：一项随机，开放标签，交叉试验
3. Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion. [J] . Pickup JC, Sutton AJ Diabetic medicine: A journal of the British Diabetic Association . 2008,第7期

机译：1型糖尿病的严重低血糖症和血糖控制：每日多次胰岛素注射与连续皮下注射胰岛素的荟萃分析。
4. Comparing artificial pancreas controlled by hybrid "closed-loop" machine learning (ML) trained algorithm to multi-daily injection (MDI), insulin pump without CGM and "sensor assisted" insulin pump therapies for Diabetes Type 1 (DT1) treatment [C] . Joan Carles Peiró International Conference on Data Analytics for Business and Industry: Way Towards a Sustainable Economy . 2020

机译：将通过混合“闭环”机器学习（ML）控制的人工胰腺培训算法对多日注于多日注射（MDI），胰岛素泵而没有CGM和“传感器辅助”胰岛素泵疗法1型（DT1）处理
5. Evaluating Hypoglycemic Risk of Two Basal Insulin Delivery Methods for Type 1 Diabetes: A Comparison of Tresiba Insulin Against Continuous Subcutaneous Insulin Infusion Using Data from Continuous Glucose Monitors [D] . Lane, Benjamin. 2020

机译：评估1型糖尿病两种基础胰岛素递送方法的低血糖风险：使用来自连续葡萄糖监测器的数据进行TRESIBA胰岛素对连续皮下胰岛素输注的比较
6. Therapy adjustments in people with type 1 diabetes with impaired hypoglycemia awareness on multiple daily injections using real-time continuous glucose monitoring: a mechanistic analysis of the HypoDE study [O] . Delia Waldenmaier, Guido Freckmann, Stefan Pleus, 2021

机译：使用实时连续葡萄糖监测的患有1型糖尿病患者患有1型糖尿病患者的糖尿病患者的治疗调整：对低钠研究的机制分析
7. Therapy adjustments in people with type 1 diabetes with impaired hypoglycemia awareness on multiple daily injections using real-time continuous glucose monitoring: a mechanistic analysis of the HypoDE study [O] . Delia Waldenmaier, Guido Freckmann, Stefan Pleus, 2021

机译：使用实时连续葡萄糖监测的患有1型糖尿病患者患有1型糖尿病患者的糖尿病患者的治疗调整：对低钠研究的机制分析

Real-time continuous glucose monitoring in adults with type 1 diabetes and impaired hypoglycaemia awareness or severe hypoglycaemia treated with multiple daily insulin injections (HypoDE): a multicentre, randomised controlled trial

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