• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in HIV and AIDS >Challenges for structure-based HIV vaccine design.
【24h】

Challenges for structure-based HIV vaccine design.

机译：基于结构的艾滋病毒疫苗设计面临的挑战。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE OF REVIEW: We review structural information on the native HIV envelope trimer and the known epitopes for broadly neutralizing antibodies and discuss how this structural information should guide the design of more effective immunogens. RECENT FINDINGS: Recent epitope mapping of HIV-positive sera demonstrates that the immune system is able to mount a potent and broadly neutralizing antibody response against conserved elements of the HIV envelope. The structure of trimeric envelope spikes on intact HIV-1 virions (the target of neutralizing antibodies) was determined at low resolution using cryo-electron tomography. Fitting high-resolution crystal structures of monomeric gp120 complexed with different neutralizing ligands into the cryo-electron density maps provides useful models for the native virion trimer and for mechanisms of neutralization. SUMMARY: So far, all attempts to elicit broadly neutralizing antibodies against HIV by immunization have failed. Recent structural information on the virion-associated HIV envelope spike and of the precise interaction of broadly neutralizing mAbs with their epitopes clarifies the steric and geometric constraints faced by antibodies targeting conserved HIV epitopes. Implications for vaccine design are discussed.
机译：审查目的：我们审查有关天然HIV包膜三聚体的结构信息以及广泛中和抗体的已知表位，并讨论该结构信息应如何指导更有效的免疫原设计。最近的发现：HIV阳性血清的最新表位作图表明，免疫系统能够对HIV包膜的保守成分产生有效且广泛中和的抗体反应。完整的HIV-1病毒体（中和抗体的靶标）上的三聚体包膜尖峰的结构使用低温电子断层扫描以低分辨率测定。将与不同中和配体复合的单体gp120的高分辨率晶体结构拟合到低温电子密度图中，可为天然病毒体三聚体和中和机制提供有用的模型。简介：迄今为止，所有通过免疫引发广泛中和针对HIV的抗体的尝试均告失败。关于病毒体相关的HIV包膜刺的最新结构信息以及广泛中和的mAb与它们的表位的精确相互作用，阐明了靶向保守的HIV表位的抗体所面临的空间和几何限制。讨论了疫苗设计的意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号