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首页> 外文期刊>Current opinion in HIV and AIDS >Renal disease in HIV-infected individuals.
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Renal disease in HIV-infected individuals.

机译：艾滋病毒感染者的肾脏疾病。

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PURPOSE OF REVIEW: Highly active antiretroviral therapy (HAART) has resulted in a marked decrease in AIDS-related conditions and death. With improved survival, cardiovascular disease, hepatic, renal disease, and non-AIDS-related cancers represent an increasing burden for HIV-infected individuals. RECENT FINDINGS: HIV-associated nephropathy (HIVAN), acute renal injury, HAART, and comorbid conditions such as hepatitis C, hypertension, and diabetes are among the multiple causes of renal disease. In HIVAN there is incomplete understanding of the interaction of the virus with renal cells and the host genetics leading to susceptibility to this form of renal dysfunction. There is agreement that a baseline estimated glomerular filtration should be obtained and that renal function should be monitored during antiretroviral therapy. There is, however, no agreement as to the most accurate method of estimating GFR. Renal transplantation has emerged as a feasible and successful modality of management of end-stage renal disease (ESRD) in HIV-infected individuals. SUMMARY: Kidney disease represents an increasing concern in the care of HIV-infected persons, although there are questions remaining regarding the pathophysiology of HIVAN. Transplantation, however, can be carried out safely in infected persons with ESRD.
机译：审查目的：高效的抗逆转录病毒疗法（HAART）已导致与艾滋病相关的疾病和死亡人数显着减少。随着生存率的提高，心血管疾病，肝癌，肾病和与艾滋病无关的癌症对艾滋病毒感染者的负担日益增加。最近的发现：HIV相关性肾病（HIVAN），急性肾损伤，HAART和合并症（例如丙型肝炎，高血压和糖尿病）是导致肾脏疾病的多种原因。在HIVAN中，对病毒与肾细胞和宿主遗传学之间相互作用的理解还不完全，导致易患这种形式的肾功能不全。同意应获得基线估计的肾小球滤过率，并应在抗逆转录病毒治疗期间监测肾功能。但是，对于估算GFR的最准确方法尚无共识。肾移植已经成为在HIV感染者中管理终末期肾病（ESRD）的可行且成功的方式。简介：尽管对HIVAN的病理生理学仍有疑问，但肾脏疾病在HIV感染者的护理中越来越引起人们的关注。但是，可以在ESRD感染者中安全地进行移植。

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