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首页> 外文期刊>Current opinion in HIV and AIDS >Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control.
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Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control.

机译：与免疫控制有关的HIV特异性CD8 + T细胞反应的定性特征。

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摘要

PURPOSE OF REVIEW: Over the past 2 years, a clearer picture has emerged regarding the properties of HIV-specific CD8+ T cells associated with immunologic control of HIV replication. These properties represent a potential mechanism by which rare patients might control HIV replication in the absence of antiretroviral therapy. This review addresses the background and recent findings that have lead to our current understanding of these mechanism(s). RECENT FINDINGS: Patients with immunologic control of HIV are not distinguished by targeted specificities, or greater numbers or breadth of their HIV-specific CD8+ T-cell response. For this reason, recent work has focused greater attention on qualitative features of this response. The qualitative features most closely associated with immunologic control of HIV are related to the granule-exocytosis-mediated elimination of HIV-infected CD4 T cells. The ability of HIV-specific CD8+ T cells to increase their contents of proteins known to mediate cytotoxicity, such as granzyme B and perforin, appears to be a critical means by which HIV-specific cytotoxic capacity is regulated. SUMMARY: Investigation from multiple groups has now focused upon HIV-specific CD8+ T-cell granule-exocytosis-mediated cytotoxicity as a correlate of immunologic control of HIV. In the near future, a more detailed understanding of the qualities associated with immunologic control may provide critical insights regarding the necessary features of a response that should be stimulated by immunotherapies or T-cell-based vaccines.
机译：审查的目的：在过去的两年中，关于与HIV复制的免疫控制有关的HIV特异性CD8 + T细胞的特性有了更清晰的认识。这些特性代表了潜在的机制，通过这种机制，罕见的患者可以在没有抗逆转录病毒疗法的情况下控制HIV的复制。这篇综述阐述了导致我们目前对这些机制了解的背景和最新发现。最近的发现：艾滋病毒免疫控制的患者没有针对性的特异性，或者他们的HIV特异性CD8 + T细胞反应的数量或范围更大。因此，最近的工作将更多的注意力集中在此响应的定性特征上。与HIV的免疫控制最密切相关的定性特征与颗粒胞吐作用介导的HIV感染的CD4 T细胞的清除有关。 HIV特异性CD8 + T细胞增加其已知介导细胞毒性的蛋白质（如颗粒酶B和穿孔素）的含量的能力似乎是调节HIV特异性细胞毒性能力的关键手段。简介：来自多个小组的研究现在集中在HIV特异性CD8 + T细胞颗粒-胞吐作用介导的细胞毒性作为HIV免疫控制的相关因素。在不久的将来，对与免疫控制相关的质量的更详细的了解可能会提供有关应由免疫疗法或基于T细胞的疫苗刺激的应答的必要特征的重要见解。

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