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首页> 外文期刊>Current opinion in lipidology >High-density lipoproteins as therapeutic targets.
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High-density lipoproteins as therapeutic targets.

机译：高密度脂蛋白作为治疗靶标。

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PURPOSE OF REVIEW: The concentration of cholesterol in HDL is an inverse predictor of future cardiovascular disease, with evidence mounting that therapies that increase HDL concentration are antiatherogenic. The best known antiatherogenic function of HDL particles relates to their ability to promote the efflux of cholesterol from cells. However, they also have antioxidant, antiinflammatory and antithrombotic properties. RECENT FINDINGS: The past year has seen the publication of several papers that highlight a potential major protective role of HDL in states of acute inflammation. Papers showing extremely promising results using novel inhibitors of cholesteryl ester transfer protein as HDL-raising agents have also appeared. Finally, the discovery that ATP-binding cassette transporter G1 (ABCG1) transports cell cholesterol to large HDL particles in the extracellular space has largely reconciled apparent inconsistencies between basic research indicating that small, pre-beta-migrating HDL particles are theantiatherogenic components of HDL and epidemiological research that implicates larger HDL particles as the protective fraction. SUMMARY: The finding that ABCG1 promotes the efflux of cholesterol from cells to large HDL particles also provides powerful circumstantial evidence that cholesteryl ester transfer protein inhibition (which increases HDL size) may enhance, rather than reduce, cholesterol efflux, and thus inhibit the development of atherosclerosis.
机译：审查的目的：高密度脂蛋白胆固醇浓度是未来心血管疾病的逆向预测因子，有证据表明增加高密度脂蛋白浓度的疗法具有抗动脉粥样硬化作用。 HDL颗粒最广为人知的抗动脉粥样硬化功能与它们促进胆固醇从细胞外排的能力有关。但是，它们也具有抗氧化，抗炎和抗血栓形成的特性。最近的发现：在过去的一年中，发表了几篇论文，这些论文强调了HDL在急性炎症状态中的潜在主要保护作用。使用胆固醇酯转移蛋白的新型抑制剂作为HDL升高剂的结果显示出极有希望的结果的论文也已经出现。最后，ATP结合盒转运蛋白G1（ABCG1）将细胞胆固醇转运到细胞外空间中较大的HDL颗粒的发现在很大程度上调和了基础研究之间的明显矛盾，这些基础研究表明，β迁移前的小HDL颗粒是HDL的抗动脉粥样硬化成分。流行病学研究涉及较大的HDL颗粒作为保护性部分。摘要：ABCG1促进胆固醇从细胞向大HDL颗粒的外排还提供了强有力的环境证据，表明胆固醇酯转移蛋白抑制作用（增加HDL大小）可以增强而不是降低胆固醇外排，从而抑制胆固醇的释放。动脉粥样硬化。

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