...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in lipidology >The endothelial glycocalyx: a potential barrier between health and vascular disease.
【24h】

The endothelial glycocalyx: a potential barrier between health and vascular disease.

机译：内皮糖萼：健康与血管疾病之间的潜在障碍。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE OF REVIEW: Although cardiovascular prevention has improved substantially, we still face the challenge of finding new targets to reduce the sequelae of atherosclerosis further. In this regard, optimizing the vasculoprotective effects of the vessel wall itself warrants intensive research. In particular, the endothelial glycocalyx, consisting of proteoglycans, glycoproteins and adsorbed plasma proteins, may play an essential role in protecting the vessel wall from atherosclerosis. RECENT DEVELOPMENTS: In this review, we will discuss the different vasculoprotective effects exerted by the endothelial glycocalyx, the factors that damage it, and the first preliminary data on the glycocalyx dimension in humans. Whereas most glycocalyx research has traditionally focused on the microvasculature, more recent data have underscored the importance of the glycocalyx in protecting the macrovasculature against pro-atherogenic insults. It has been shown that glycocalyx loss is accompanied by a wide array of unfavourable changes in both small and larger vessels. Pro-atherogenic stimuli increase the shedding of glycocalyx constituents into the circulation, contributing to the progressive loss of the vasculoprotective properties of the vessel wall. Novel techniques have facilitated reproducible measurements of systemic glycocalyx volume in humans. Consistent with experimental data, the volume of the human glycocalyx is also severely perturbed by exposure to atherogenic risk factors. SUMMARY: Cumulating evidence suggests that an intact glycocalyx protects the vessel wall, whereas disruption of the glycocalyx upon atherogenic stimuli increases vascular vulnerability for atherogenesis.
机译：审查目的：尽管心血管疾病的预防已大大改善，但我们仍然面临寻找新目标以进一步减轻动脉粥样硬化后遗症的挑战。在这方面，优化血管壁本身的血管保护作用值得深入研究。特别地，由蛋白聚糖，糖蛋白和吸附的血浆蛋白组成的内皮糖萼可能在保护血管壁免受动脉粥样硬化中起重要作用。最近的发展：在这篇综述中，我们将讨论内皮糖萼所发挥的不同的血管保护作用，破坏它的因素，以及人类糖萼维度的第一个初步数据。传统上，大多数糖萼研究都集中在微脉管系统上，而最近的数据则强调了糖萼在保护大脉管系统免受动脉粥样硬化性损伤方面的重要性。已经显示，糖萼的损失伴随着小血管和大血管中各种各样的不利变化。促动脉粥样硬化的刺激增加了糖萼成分向循环中的脱落，导致血管壁的血管保护特性逐渐丧失。新技术促进了人体中全身糖萼体积的可重复测量。与实验数据一致，人糖萼的体积也因暴露于致动脉粥样硬化的危险因素而受到严重干扰。简介：越来越多的证据表明，完整的糖萼可保护血管壁，而在动脉粥样硬化刺激作用下破坏糖萼会增加动脉粥样硬化的血管易损性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号