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首页> 外文期刊>Current opinion in lipidology >The clinical and nutritional implications of lipid-lowering drugs that act in the gastrointestinal tract.
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The clinical and nutritional implications of lipid-lowering drugs that act in the gastrointestinal tract.

机译：降脂药物在胃肠道中的临床和营养意义。

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PURPOSE OF REVIEW: A new class of cholesterol-lowering therapy that reduces intestinal sterol absorption has recently been introduced. This increases the number of classes of lipid-lowering agents that directly affect gastrointestinal function and raises questions concerning the overall effect of these agents on absorption and nutritional status. RECENT FINDINGS: A recent assessment notes a paucity of information concerning the factors that affect the bioavailability and intestinal absorption of lipophilic nutrients. By contrast, the specificity of the mechanisms of action of new drugs acting on the gastrointestinal tract may circumvent some of the detrimental effects on nutrient and drug bioavailability that have been noted with older forms of treatment. SUMMARY: The clinical imperative for aggressive control of lipid and metabolic risk factors makes widespread use, alone or in combination, of lipid-lowering agents that affect the gastrointestinal tract seem increasingly likely. Whilst the opportunityfor therapeutic synergy is attractive, care will be required to avoid interference with intestinal absorptive function.
机译：审查的目的：最近已经引入了一种新的降低胆固醇的疗法，该疗法可降低肠道甾醇的吸收。这增加了直接影响胃肠功能的降脂药的种类，并引起了关于这些药对吸收和营养状况的总体影响的疑问。最近的发现：最近的评估指出，缺乏有关影响亲脂性营养素生物利用度和肠道吸收的因素的信息很少。相比之下，新药作用于胃肠道的作用机制的特异性可能会规避某些较旧形式的治疗对营养和药物生物利用度的某些不利影响。概述：积极控制脂质和代谢危险因素的临床势在必行，越来越有可能广泛地单独或联合使用影响胃肠道的降脂药。尽管产生治疗协同作用的机会很诱人，但仍需要注意避免干扰肠道吸收功能。

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