...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Chemical receptors of the arytenoid: A comparison of human and mouse
【24h】

Chemical receptors of the arytenoid: A comparison of human and mouse

机译：arytenoid的化学受体：人与小鼠的比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives/Hypothesis The larynx is a highly responsive organ exposed to mechanical, thermal, and chemical stimuli. Chemicals elicit responses both in intraepithelial nerve fibers and in specialized chemosensory cells, including scattered solitary cells as well as taste cells organized into taste buds. Activation of both chemosensory cells and taste buds in the larynx elicit cough, swallow, or apnea with exposure to sour or bitter substances, and even by water or sweet‐tasting chemicals. In an effort to begin understanding their function, we sought to compare the distribution, density, and types of chemosensory cells and chemoresponsive nerve fibers in laryngeal epithelium of humans and mice. Study Design Animal and human laboratory analysis. Methods Using immunohistochemistry, we identified taste cells and polymodal nociceptive nerve fibers in the arytenoid area of the laryngeal epithelium of the following: 1) infants undergoing supraglottoplasty for laryngomalacia, and 2) a cadaveric specimen procured from a 34‐year‐old donor. We then compared these findings to both preweanling and mature mouse tissue. Results Arytenoid tissue from both human and mouse contained many taste buds containing type II taste cells—bitter, sweet, or umami sensing—which were innervated by nerve fibers expressing P2X3 type adenosine triphosphate receptors. Type III cells (acid responsive) were also present, but they were fewer in human tissue than in equivalent tissue from mice. In both species, the epithelium was densely innervated by free nerve endings. Conclusions Our findings suggest that from a standpoint of chemosensation, human and mouse larynges are biologically similar. This suggests that a murine model can be used effectively in laryngeal chemosensory research. Level of Evidence NA Laryngoscope , 130:423–430, 2020
机译：目标/假设喉部是一种高度反应的器官，暴露于机械，热和化学刺激。化学品在上皮内神经纤维和专用化学感染细胞中引出反应，包括散射的孤立细胞以及组织成味蕾的味道细胞。在喉部咳嗽，吞咽或呼吸暂停中的乳清露咳嗽，吞咽或呼吸暂停的激活，甚至通过水或甜味化学品。在开始了解其功能的努力，我们试图比较的分布，密度和化学感觉细胞和人类和小鼠的喉上皮chemoresponsive神经纤维的类型。研究设计动物和人力实验室分析。使用免疫组织化学的方法，我们鉴定了喉头上皮细胞的味道细胞和多种多体伤害神经纤维以下：1）患有喉头形成术的婴儿，2）由34岁的供体采购的尸体标本。然后，我们将这些发现与普生和成熟的小鼠组织进行了比较。结果来自人和小鼠的Arytenoid组织含有许多含有II型味肠的味蕾 - 苦味，甜或umami感测 - 通过表达P2x3型腺苷三磷酸受体的神经纤维所分析。还存在III型细胞（酸响应性），但它们在人体组织中比来自小鼠的等效组织更少。在这两种物种中，上皮细胞被游离神经末梢密集地接受。结论我们的研究结果表明，从化学化的观点来看，人和小鼠喉部是生物学上的。这表明鼠模型可以有效地用于喉部化学感化研究。证据水平na喉镜，130：423-430,2020

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号