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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Congenital laryngomalacia: Is it an inflammatory disease? The role of vitamin D
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Congenital laryngomalacia: Is it an inflammatory disease? The role of vitamin D

机译：先天性喉头喉：是炎症疾病吗？ 维生素D的作用

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Objectives/Hypothesis Laryngomalacia is the most common cause of stridor in infants. The exact pathophysiology is still not well understood. Our objective was to investigate whether laryngomalacia is an inflammatory disease, focusing on the possible role of vitamin D. Study Design Case‐control study. Methods Sixty Egyptian infants and 60 mothers were included in this study. They were divided into four equal groups (n = 30 for each): infants with laryngomalacia (LM‐infants), control infants (C‐infants), mothers of the infants with laryngomalacia (LM‐mothers), and mothers of the control infants (C‐mothers). Laryngoscopy was performed and serum 25‐hydroxyvitamin D (25[OH]‐vitamin‐D) and interleukin 6 (IL‐6) were estimated. Results Significant increase of serum IL‐6 associated with a significant decrease in serum 25(OH)‐vitamin D was observed in the LM‐infants compared to the C‐infants ( P .001 for both). LM‐mothers had significantly lower 25(OH)‐vitamin D status compared to C‐mothers ( P .001). Conclusions Deficiency of 25(OH)‐vitamin D in LM‐infants may result in dysregulation of the immune responses with elevation of a proinflammatory cytokine (IL‐6). Laryngomalacia could be an inflammatory disease due to 25(OH)‐vitamin D deficiency as evidenced by the high level of IL‐6. This finding may open the door to the appropriate prevention, diagnosis, and treatment, especially for moderate to severe laryngomalacia. Level of Evidence 3b Laryngoscope , 130:448–453, 2020
机译：目标/假说喉症是婴幼儿喘鸣的最常见原因。确切的病理生理机制仍然没有很好的理解。我们的目标是调查是否喉症是一种炎症性疾病，专注于维生素D研究设计病例对照研究中的作用。方法60名埃及婴儿和母亲60被列入这项研究。他们被分成四个相等的组（n = 30对于每个）：婴儿喉（LM-婴儿），控制婴儿（C-婴儿），与喉（LM-母亲）的婴儿的母亲，和母亲的控制婴儿（C-母亲）。喉镜进行和血清25-羟基d（25 [OH] - 维生素-d）和白细胞介素6（IL-6）估计。结果血清IL-6显着增加与血清25（OH）一个显著减少相关 - 维生素在LM-婴儿中观察到d相比，C-婴儿（P＆LT; .001两者）。相比于C-母亲（; 0.001 P＆LT）LM-母亲有显著低25（OH） - 维生素d状态。 25结论缺乏症（OH） - 维生素d在LM-婴儿可能导致具有促炎细胞因子（IL-6）的高程的免疫反应的失调。喉症可以是如由高电平IL-6的炎症性疾病是由于25（OH） - 维生素d缺乏。这一发现可能打开门到相应的预防，诊断和治疗，特别是对于中，重度喉症。证据3B喉镜的水平，130：448-453 2020年

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