Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders.

Howard E Gendelman; Harris A Gelbard

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Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders.

机译：与艾滋病毒相关的神经认知障碍的辅助性和长效纳米配方抗逆转录病毒疗法。

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Antiretroviral therapy has improved the quality and duration of life for people living with HIV-1. A significant long-term comorbid illness is HIV-associated neurocognitive disorders. Symptoms, although reduced in severity, are common. Disease occurs, in part, through continued low-level viral replication, inducing secondary glial neuroinflammatory activities. Our recent works and those of others have seen disease attenuated in animal models through the use of adjunctive and long-acting reservoir-targeted nanoformulated antiretroviral therapy. The translation of these inventions from animals to humans is the focus of this review.

机译：抗逆转录病毒疗法改善了HIV-1感染者的生活质量和寿命。与艾滋病毒相关的神经认知障碍是一种长期的重大合并症。症状虽然严重程度有所降低，但很常见。疾病的发生部分是通过持续的低水平病毒复制，诱导继发的神经胶质神经炎活动。我们最近的工作和其他工作，已通过使用辅助性和长效储库靶向纳米制剂抗逆转录病毒疗法在动物模型中减轻了疾病。这些发明从动物到人类的翻译是本文的重点。

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《Current opinion in HIV and AIDS》 |2014年第6期|共6页
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Howard E Gendelman; Harris A Gelbard;
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1. Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders. [J] . Howard E Gendelman, Harris A Gelbard Current opinion in HIV and AIDS . 2014,第6期

机译：与艾滋病毒相关的神经认知障碍的辅助性和长效纳米配方抗逆转录病毒疗法。
2. Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice [J] . DashP.K., GendelmanH.E., RoyU., AIDS . 2012,第17期

机译：长效纳米配方抗逆转录病毒疗法在感染HIV-1的人源化小鼠中引起有效的抗逆转录病毒和神经保护反应
3. EVALUATION OF COMBINATION LONG-ACTING NANOFORMULATED ANTIRETROVIRAL THERAPY IN EARLY HIV-1 INFECTED huPBL NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ MICE [J] . Su Hang, Dash Prasanta, Arainga Mariluz, Journal of neurovirology . 2016,第Suppla1期

机译：HIV-1早期感染的huPBL NOd.Cg-Prkdcscid Il2rgtm1Wjl / SzJ小鼠长效纳米配方抗病毒治疗的联合评价
4. Construction of Knowledge Graph of HIV-associated Neurocognitive Disorders Syndrome based on Deep Learning [C] . Di Sun, Yang Peng, Hongjun Li International Conference on Artificial Intelligence and Computer Engineering . 2020

机译：基于深度学习的艾滋病相关神经认知障碍综合征的知识图构建
5. Assessing the contribution of antiretroviral therapy to neuronal damage and death as a mediator of cognitive decline in HIV-associated neurocognitive disorders. [D] . Gannon, Patrick Joseph. 2014

机译：评估抗逆转录病毒疗法对神经元损害和死亡的贡献，作为与HIV相关的神经认知障碍的认知能力下降的中介。
6. Adjunctive and Long-Acting Nanoformulated Antiretroviral Therapies for HIV-associated neurocognitive disorders [O] . Howard E. Gendelman, Harris A. Gelbard -1

机译：艾滋病毒相关神经认知障碍的辅助和长效纳米配方抗逆转录病毒疗法
7. Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice [O] . Prasanta K. Dash, Howard E. Gendelman, Upal Roy, 2012

机译：长效纳米型抗逆转录病毒治疗引发有效的抗逆转录病毒和神经保护反应在HIV-1感染的人源化小鼠中

Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders.

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