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首页> 外文期刊>Current opinion in lipidology >Monocyte chemotactic protein-1 and its role in insulin resistance.
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Monocyte chemotactic protein-1 and its role in insulin resistance.

机译：单核细胞趋化蛋白-1及其在胰岛素抵抗中的作用。

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摘要

PURPOSE OF REVIEW: In obesity, there is a strong link between increased adipose tissue mass and development of insulin resistance in tissues such as liver and muscle. Under these conditions, adipose tissue synthesizes various pro-inflammatory chemokines such as monocyte chemotactic protein-1. This review provides a summary of recent knowledge on the role of monocyte chemotactic protein-1 in adipose tissue inflammation and insulin resistance. RECENT FINDINGS: Monocyte chemotactic protein-1 is a proinflammatory adipokine that is believed to play a role in the pathogenesis of obesity and diabetes. New in-vitro data demonstrate that monocyte chemotactic protein-1 has the ability to induce insulin resistance in adipocytes and skeletal muscle cells. By using mice that either overexpress monocyte chemotactic protein-1 or are deficient in monocyte chemotactic protein-1 or its receptor, exciting new insights have been obtained into the role of monocyte chemotactic protein-1 in adipose tissue inflammation and insulin resistance. SUMMARY: Monocyte chemotactic protein-1 is an adipokine with insulin-resistance-inducing capacity that is related to increased adipose tissue mass in obesity and insulin resistance. It plays an important role in adipose tissue inflammation by recruiting macrophages into fat. Monocyte chemotactic protein-1 is thus a therapeutic target, and may represent an important factor linking adipose tissue inflammation, obesity and type 2 diabetes.
机译：审查目的：在肥胖症中，脂肪组织的增加与肝脏和肌肉等组织中胰岛素抵抗的发展之间存在密切的联系。在这些条件下，脂肪组织合成各种促炎趋化因子，例如单核细胞趋化蛋白-1。这篇综述提供了有关单核细胞趋化蛋白-1在脂肪组织炎症和胰岛素抵抗中作用的最新知识的综述。最近的发现：单核细胞趋化蛋白1是一种促炎性脂肪因子，据信在肥胖症和糖尿病的发病机理中起作用。新的体外数据表明，单核细胞趋化蛋白1具有诱导脂肪细胞和骨骼肌细胞中胰岛素抵抗的能力。通过使用过表达单核细胞趋化蛋白-1或单核细胞趋化蛋白-1或其受体不足的小鼠，令人兴奋的新见解已成为单核细胞趋化蛋白-1在脂肪组织炎症和胰岛素抵抗中的作用。摘要：单核细胞趋化蛋白-1是一种具有胰岛素抵抗诱导能力的脂肪因子，与肥胖和胰岛素抵抗中脂肪组织增加有关。它通过将巨噬细胞募集到脂肪中而在脂肪组织炎症中起重要作用。因此，单核细胞趋化蛋白1是治疗靶标，并且可能代表联系脂肪组织炎症，肥胖症和2型糖尿病的重要因素。

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