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首页> 外文期刊>Current opinion in lipidology >Novel developments in omega-3 fatty acid-based strategies.
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Novel developments in omega-3 fatty acid-based strategies.

机译：基于omega-3脂肪酸的策略的新发展。

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PURPOSE OF REVIEW: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been attributed with several health benefits, including triglyceride lowering and cardiovascular disease risk reduction. This review focuses on new prescription omega-3 fatty acid products in development and recently published data regarding omega-3 fatty acid effects on arrhythmias, heart failure, and platelet inactivation. RECENT FINDINGS: A free fatty acid form of n-3 PUFA was found to produce a four-fold higher area under the plasma n-3 PUFA curve than prescription omega-3-acid ethyl esters in patients on a low-fat diet. Eicosapentaenoic acid ethyl esters reduced triglyceride without significantly elevating LDL cholesterol in patients with severe hypertriglyceridemia and in those with mixed dyslipidemia. Recent investigations of n-3 PUFA effects on ventricular and atrial arrhythmias, including studies in patients with implanted defibrillators, failed to demonstrate a significant benefit. However, increased fatty fish or n-3 PUFA consumption was associated with a lower rate of hospitalization in heart failure patients. A further important finding was potentiation of the antiplatelet response when n-3 PUFAs were added to aspirin + clopidogrel. SUMMARY: Although n-3 PUFA therapy continues to show promise in the prevention and management of cardiovascular diseases, further research is necessary to more fully elucidate its role in specific disorders.
机译：审查目的：Omega-3多不饱和脂肪酸（n-3 PUFA）具有多种健康益处，包括降低甘油三酸酯和降低心血管疾病的风险。这篇综述主要关注正在开发的新处方omega-3脂肪酸产品，以及最近发表的有关omega-3脂肪酸对心律不齐，心力衰竭和血小板失活的影响的数据。最新发现：在低脂饮食患者中，n-3 PUFA的游离脂肪酸形式在血浆n-3 PUFA曲线下产生的面积比处方omega-3-酸乙酯高4倍。对于严重的高甘油三酯血症和混合血脂异常的患者，二十碳五烯酸乙酯可降低甘油三酯而不会显着升高LDL胆固醇。最近对n-3 PUFA对心室和房性心律不齐的影响的研究，包括对植入了除颤器的患者的研究，均未显示出明显的益处。但是，心律不齐患者中脂肪鱼的增加或n-3 PUFA的摄入与住院率降低有关。另一个重要发现是，当向阿司匹林+氯吡格雷中添加n-3 PUFA时，可增强抗血小板反应。简介：尽管n-3 PUFA疗法在心血管疾病的预防和控制方面继续显示出希望，但仍需要进一步研究以更充分地阐明其在特定疾病中的作用。

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