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首页> 外文期刊>Current opinion in lipidology >Postprandial dyslipidaemia and diabetes: Mechanistic and therapeutic aspects
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Postprandial dyslipidaemia and diabetes: Mechanistic and therapeutic aspects

机译：餐后血脂异常和糖尿病：机制和治疗方面

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Purpose of Review: There has been a resurgence of interest in the role of triglyceride-rich lipoproteins in the development of atherosclerosis and cardiovascular disease, and this is particularly relevant to diabetes mellitus and the postprandial state. Recent Findings: Recent evidence suggests that insulin resistance in diabetes induces postprandial dyslipidemia by increasing the enterocytic production of chylomicrons and their remnant particles, but an impaired clearance capacity is also involved. Postprandial dyslipidaemia in diabetes induces oxidative stress, inflammation and endothelial dysfunction and this may be compounded by dysglycaemia. New guidelines for managing hypertriglyceridaemia in diabetes have been published, first-line therapies being improved glycaemic control, treatment of other secondary causes of dyslipidaemia and statin therapy, followed by judicious use of fibrates, n-3 fatty acids or niacin. A new role for incretin-based therapies in regulating dyslipidaemia has been identified. Summary: Postprandial dyslipidaemia is a pivotal mechanism whereby diabetes can induce and accelerate atherosclerosis. Regulating the plasma concentrations of triglyceride-rich lipoproteins may decrease the cardiovascular complications of diabetes. The mechanisms of action of incretin-based treatments on dyslipidaemia and endothelial dysfunction need further investigation. The efficacy of new therapies targeted at postprandial dysmetabolism in diabetes need to be confirmed, against best current levels of care, in clinical endpoint trials.
机译：审查目的：人们对富含甘油三酸酯的脂蛋白在动脉粥样硬化和心血管疾病的发展中的作用重新产生兴趣，这尤其与糖尿病和餐后状态有关。最新发现：最近的证据表明，糖尿病中的胰岛素抵抗会通过增加乳糜微粒及其残留颗粒的肠细胞产生而诱发餐后血脂异常，但清除能力也会下降。糖尿病的餐后血脂异常会引起氧化应激，炎症和内皮功能障碍，这可能与血脂异常加重。已经发布了治疗糖尿病中高甘油三酯血症的新指南，一线疗法是改善血糖控制，治疗血脂异常的其他继发原因和他汀类药物疗法，然后明智地使用贝特类，n-3脂肪酸或烟酸。已经确定了基于肠降血糖素的疗法在调节血脂异常中的新作用。简介：餐后血脂异常是糖尿病可以诱发和加速动脉粥样硬化的关键机制。调节富含甘油三酸酯的脂蛋白的血浆浓度可以减少糖尿病的心血管并发症。肠降血糖素治疗血脂异常和内皮功能障碍的作用机制有待进一步研究。在临床终点试验中，针对目前最佳的护理水平，需要确认针对糖尿病餐后代谢异常的新疗法的有效性。

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