Structure and function of apolipoprotein A-I and high-density lipoprotein.

Segrest JP; Li L; Anantharamaiah GM; Harvey SC; Liadaki KN; Zannis V

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Structure and function of apolipoprotein A-I and high-density lipoprotein.

机译：载脂蛋白A-1和高密度脂蛋白的结构和功能。

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Structural biology and molecular modeling have provided intriguing insights into the atomic details of the lipid-associated structure of the major protein component of HDL, apo A-I. For the first time, an atomic resolution map is available for future studies of the molecular interactions of HDL in such biological processes as ABC1-regulated HDL assembly, LCAT activation, receptor binding, reverse lipid transport and HDL heterogeneity. Within the context of this paradigm, the current review summarizes the state of HDL research.

机译：结构生物学和分子建模为HDL主要蛋白成分载脂蛋白A-I的脂质相关结构的原子细节提供了有趣的见解。原子分辨率图谱首次可用于将来在诸如ABC1调节的HDL组装，LCAT活化，受体结合，反向脂质转运和HDL异质性等生物学过程中对HDL分子相互作用的研究。在这种范式的背景下，本篇综述总结了HDL研究的现状。

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来源
《Current opinion in lipidology》 |2000年第2期|共11页
作者
Segrest JP; Li L; Anantharamaiah GM; Harvey SC; Liadaki KN; Zannis V;
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正文语种 eng
中图分类生物化学;
关键词
Apolipoprotein A-I; Lipoproteins; HDL; discoidal lipoproteins; Lipoproteins; 载脂蛋白A-Ⅰ; 脂蛋白类; HDL;

机译：Apolipoprotein A-I;Lipoproteins;HDL;discoidal lipoproteins;Lipoproteins;载脂蛋白A-Ⅰ;脂蛋白类;HDL;

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专利

1. Structure/function relationships of apolipoprotein a-I mimetic peptides: implications for antiatherogenic activities of high-density lipoprotein. [J] . DSouza W, Stonik JA, Murphy A, Circulation research: a journal of the American Heart Association . 2010,第2期

机译：载脂蛋白α-I模拟肽的结构/功能关系：对高密度脂蛋白抗动脉粥样硬化活性的影响。
2. Anti-inflammatory functions of apolipoprotein A-I and high-density lipoprotein are preserved in trimeric apolipoprotein A-I [J] . MurphyA.J., HoangA., ApricoA., The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2013,第1期

机译：三聚体载脂蛋白A-I保留了载脂蛋白A-I和高密度脂蛋白的抗炎功能
3. The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. [J] . Kozyraki R, Fyfe J, Kristiansen M, Nature medicine . 1999,第6期

机译：固有因子-维生素B12受体cubilin是促进高密度脂蛋白内吞的高亲和力载脂蛋白A-1受体。
4. Structural and Functional Consequences of a Single Amino Acid Deletion in the C-Terminal Region of Apolipoprotein A-I [C] . Masafumi Tanaka, Toshitaka Tanaka, Sissel Lund-Katz Japanese peptide symposium . 2010

机译：载脂蛋白A-1的C末端区域中单个氨基酸缺失的结构和功能后果
5. Effects of oxidation, particle size, and protein composition on structure and stability of high-density lipoprotein. [D] . Gao, Xuan. 2010

机译：氧化，粒径和蛋白质组成对高密度脂蛋白结构和稳定性的影响。
6. A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein [O] . Xiaodong Gu, Zhiping Wu, Ying Huang, 2016

机译：高密度脂蛋白载脂蛋白A-I /卵磷脂胆固醇酰基转移酶相互作用环的结构/功能要求的系统研究
7. Structure of apolipoprotein A-I's N-terminus on nascent high density lipoprotein. [O] . Lagerstedt, Jens, Cavigiolio, Giorgio, Budamagunta, Madhu S, 2011

机译：载脂蛋白a-I的N-末端在新生高密度脂蛋白上的结构。

Structure and function of apolipoprotein A-I and high-density lipoprotein.

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