...
首页> 外文期刊>Current opinion in lipidology >Cubilin, a high-density lipoprotein receptor.
【24h】

Cubilin, a high-density lipoprotein receptor.

机译:Cubilin,一种高密度脂蛋白受体。

获取原文
获取原文并翻译 | 示例
           

摘要

The metabolism of HDL particles is a complex biological process involving various regulating factors in plasma and different cellular receptors. In addition to the well-established scavenger receptor BI-mediated selective HDL-cholesteryl ester uptake in liver and steroidogenic tissues, evidence has been provided that HDL also undergoes holoparticle endocytosis in different tissues. Recently, a novel receptor expressed in various absorptive epithelia was disclosed as a high affinity receptor for endocytosis of HDL and lipid-poor apolipoprotein AI. This receptor, designated cubilin, may play an important role in the renal clearance of filterable apolipoprotein AI/HDL and in the maternal-fetal transport of cholesterol.
机译:HDL颗粒的代谢是一个复杂的生物过程,涉及血浆中的各种调节因子和不同的细胞受体。除了在肝脏和类固醇生成组织中公认的清道夫受体BI介导的选择性HDL-胆固醇酯摄取之外,还提供了HDL在不同组织中也经历全颗粒内吞作用的证据。最近,在各种吸收性上皮中表达的新型受体被公开为高亲和力受体,用于HDL和贫脂载脂蛋白AI的胞吞作用。该受体称为cubilin,可能在可过滤载脂蛋白AI / HDL的肾脏清除率以及胆固醇的母胎运输中起重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号