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首页> 外文期刊>The Journal of Experimental Biology >Differences in molecular mechanisms of K+ clearance in the auditory sensory epithelium of birds and mammals
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Differences in molecular mechanisms of K+ clearance in the auditory sensory epithelium of birds and mammals

机译：鸟类和哺乳动物听觉感觉上皮k +间隙分子机制的差异

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摘要

Mechanoelectrical transduction in the vertebrate inner ear is a highly conserved mechanism that is dependent on K+ influx into hair cells. Here, we investigated the molecular underpinnings of subsequent K+ recycling in the chicken basilar papilla and compared them with those in the mammalian auditory sensory epithelium. As in mammals, the avian auditory hair cell uses KCNQ4, KCNMA1 and KCNMB1 in its K+ efflux system. Expression of KCNQ1 and KCNE1 suggests an additional efflux apparatus in avian hair cells. Marked differences were observed for K+ clearance. In mammals, KCC3, KCC4, Kir4.1 and CLC-K are present in supporting cells. Of these, only CLC-K is expressed in avian supporting cells. Instead, they possess NKCC1 to move K+ across the membrane. This expression pattern suggests an avian clearance mechanism reminiscent of the well-established K+ uptake apparatus present in inner ear secretory cells. Altogether, tetrapod hair cells show similar mechanisms and supporting cells show distinct molecular underpinnings of K+ recycling.
机译：脊椎动物内耳的机械电转导是一种高度保守的机制，其取决于k +流入毛细胞。在这里，我们研究了在鸡底乳头乳乳头中随后的K +再循环的分子支撑，并将其与哺乳动物听觉性上皮中的乳头相比。与哺乳动物一样，禽耳听风机在其K + Efflux系统中使用KCNQ4，KCNMA1和KCNMB1。 KCNQ1和KCNE1的表达表明禽毛细胞中的额外排出装置。 k +间隙观察到显着的差异。在哺乳动物中，KCC3，KCC4，KIR4.1和CLC-K存在于支撑细胞中。其中，只有CLC-K在禽类支持细胞中表达。相反，它们具有NKCC1在膜上移动k +。该表达模式表明了一种禽流性的间隙机制，使内耳分泌细胞中存在的良好的K +摄取装置。完全，Tetrapod毛细胞显示出类似的机制和支撑细胞显示K +再循环的不同分子下限。

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