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首页> 外文期刊>Current opinion in lipidology >A proatherogenic role for C-reactive protein in vivo.
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A proatherogenic role for C-reactive protein in vivo.

机译：体内C反应蛋白的促动脉粥样硬化作用。

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PURPOSE OF REVIEW: We have selectively reviewed some of the latest papers on the mechanistic role of C-reactive protein in atherosclerotic cardiovascular disease. RECENT DEVELOPMENTS: C-reactive protein is known to activate the classic pathway of the complement system. One paper examined the role of C-reactive protein in complement activation by enzymatically remodeled LDL proteins. Enzymatically remodeled LDL was found to induce complement activation with or without C-reactive protein, but in the presence of C-reactive protein the activation of complement halted before its terminal sequence. Complement activation by C-reactive protein in atherogenesis remains controversial. Different laboratories have reported the multi-organ origin of C-reactive protein. The atherosclerotic lesion itself is another place where C-reactive protein could be produced. Numerous studies have continued to dissect the potential diverse proatherogenic actions of C-reactive protein on cultured vascular cells. Caution must be exercised in inadequately controlled studies that have unwittingly used commercial C-reactive protein preparations contaminated by other bioactive components. In contrast to in-vitro experiments, in-vivo studies that support a proatherogenic role of C-reactive protein are less likely to be subject to misinterpretation. SUMMARY: Evidence suggests that C-reactive protein is a proatherogenic molecule that plays an active role. The amount of C-reactive protein in lesions is determined by its plasma levels and its local production. The biological effect of C-reactive protein on atherosclerosis development seems to encompass a complex network of interactions with other players in immunity and inflammation, such as the complement system, as well as a direct effect of C-reactive protein on the cells involved in lesion growth and development.
机译：审查的目的：我们有选择地审查了一些有关C反应蛋白在动脉粥样硬化性心血管疾病中的机制作用的最新论文。最近的发展：已知C反应蛋白可激活补体系统的经典途径。一篇论文研究了C反应蛋白在酶促重塑LDL蛋白激活补体中的作用。发现经酶重塑的LDL在有或没有C反应蛋白的情况下均可诱导补体激活，但是在存在C反应蛋白的情况下，补体的激活在其末端序列之前停止。 C反应蛋白在动脉粥样硬化中的补体激活仍存在争议。不同的实验室已经报道了C反应蛋白的多器官起源。动脉粥样硬化病变本身是可以产生C反应蛋白的另一个地方。大量研究继续剖析了C反应蛋白对培养的血管细胞潜在的多种促动脉粥样硬化作用。在未充分使用被其他生物活性成分污染的商业C反应蛋白制剂的不适当对照研究中，必须谨慎行事。与体外实验相反，支持C反应蛋白促动脉粥样硬化作用的体内研究较少可能被误解。摘要：证据表明，C反应蛋白是一种促动脉粥样硬化分子，起着积极的作用。病变中C反应蛋白的含量取决于其血浆水平和局部产生。 C反应蛋白对动脉粥样硬化发展的生物学作用似乎涵盖了与免疫和炎症（例如补体系统）中其他参与者相互作用的复杂网络，以及C反应蛋白对病变细胞的直接作用增长与发展。

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