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Lipid droplet biogenesis: when the endoplasmic reticulum starts to fatten up.

机译:脂质液滴的生物发生:当内质网开始增肥时。

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摘要

Lipid droplets are energy storage organelles composed of a phospholipid monolayer surrounding a hydrophobic core of neutral lipids, mainly triacylglycerols (TAGs) and steryl esters [1]. The exact mechanisms involved in the biogenesis of lipid droplets are not well understood, as direct imaging of newly forming lipid droplets is impossible with current methodology. Nevertheless, it is widely accepted that lipid droplets form within the endoplasmic reticulum (ER) membrane, in which neutral lipid synthesis and coalescence eventually lead to a droplet budding off the membrane, with the cytoplasmic leaflet of the ER membrane forming the monolayer of the lipid droplet [2,3].
机译:脂质小滴是由磷脂单层组成的能量存储细胞器,该磷脂单层围绕中性脂质(主要是三酰基甘油(TAG))和甾醇酯的疏水核[1]。由于目前的方法无法对新形成的脂质小滴进行直接成像,因此对脂质小滴的生物发生中涉及的确切机制还没有很好的了解。然而,广泛接受的是在内质网(ER)膜内形成脂质滴,其中中性脂质合成和聚结最终导致液滴从膜上萌芽,而ER膜的细胞质小叶形成脂质的单层液滴[2,3]。

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