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首页> 外文期刊>Current opinion in lipidology >Effects of bariatric surgery on hepatic and intestinal lipoprotein particle metabolism
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Effects of bariatric surgery on hepatic and intestinal lipoprotein particle metabolism

机译：减肥手术对肝和肠脂蛋白颗粒代谢的影响

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Purpose of reviewInsulin resistance and type 2 diabetes, driven largely by obesity, are characterized by an increase in triglyceride-rich lipoproteins (TRLs) due to both reduced TRL clearance from the circulation and increased production by the liver (apoB-100 containing VLDLs) and intestine (apoB-48 containing chylomicrons). Bariatric surgery is the only treatment currently that leads to marked, sustained weight loss. Here, we will review the effects of bariatric surgery on circulating triglyceride/TRL and TRL production and clearance.Recent findingsBariatric surgery leads to a marked reduction in fasting and postprandial plasma triglyceride. Only one study to date has assessed TRL kinetics after bariatric surgery and has reported a reduction in TRL apoB-100 concentration (i.e. the number of VLDL particles) due to reduced production and increased clearance and reduced TRL apoB-48 concentration (the number of chylomicron particles) due to reduced production. Some bariatric surgery studies have reported no/weak correlation between weight loss and improvements in triglyceride/TRL, suggesting that as yet unidentified factors beyond weight loss may contribute to the marked changes in TRL that occur postbariatric surgery.SummaryAvailable data suggest that bariatric surgery reduces triglyceride and intestinal and hepatic TRL production with increased clearance of hepatic TRL particles. These effects of bariatric surgery on TRL kinetics need to be confirmed with additional studies. Further studies are also needed to compare the effects of various bariatric surgery procedures on TRL kinetics and to elucidate underlying mechanisms.
机译：审查目的胰岛素抵抗和2型糖尿病主要由肥胖引起，其特征是富含甘油三酸酯的脂蛋白（TRL）的增加，这归因于循环中TRL清除率的降低和肝脏（apoB-100含VLDLs）的分泌增加。肠（载有乳糜微粒的apoB-48）。减肥手术是目前导致明显持续体重减轻的唯一疗法。在这里，我们将回顾减肥手术对循环甘油三酸酯/ TRL和TRL产生和清除的影响。最近的发现钡餐手术可导致禁食和餐后血浆甘油三酯显着降低。迄今为止，只有一项研究评估了减肥手术后的TRL动力学，并报告了TRL apoB-100浓度降低（即VLDL颗粒数），这是由于产量减少，清除率增加以及TRL apoB-48浓度降低（乳糜微粒数）所致。颗粒）。一些减肥手术研究表明，体重减轻与甘油三酸酯/ TRL改善之间无相关性/弱相关，这表明除体重减轻外，尚不明确的因素可能会导致肥胖症患者术后TRL发生显着变化。总结数据表明，减肥手术可降低甘油三酸酯以及肠道和肝脏TRL的产生，以及肝脏TRL颗粒清除率的提高。减肥手术对TRL动力学的这些影响需要进一步研究证实。还需要进一步的研究，以比较各种减肥手术程序对TRL动力学的影响并阐明潜在的机制。

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