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首页> 外文期刊>The Veterinary Record >Clinical use of organic near-infrared fluorescent contrast agents in image-guided oncologic procedures and its potential in veterinary oncology
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Clinical use of organic near-infrared fluorescent contrast agents in image-guided oncologic procedures and its potential in veterinary oncology

机译：有机近红外荧光造影剂的临床应用在图像引导的脑卒中程序中及其在兽医肿瘤学中的潜力

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摘要

One of the major challenges in surgical oncology is the intraoperative discrimination of tumoural versus healthy tissue. Until today, surgeons rely on visual inspection and palpation to define the tumoural margins during surgery and, unfortunately, for various cancer types, the local recurrence rate thus remains unacceptably high. Near-infrared (NIR) fluorescence imaging is an optical imaging technique that can provide real-time preoperative and intraoperative information after administration of a fluorescent probe that emits NIR light once exposed to a NIR light source. This technique is safe, cost-effective and technically easy. Several NIR fluorescent probes are currently studied for their ability to highlight neoplastic cells. In addition, NIR fluorescence imaging holds great promise for sentinel lymph node mapping. The aim of this manuscript is to provide a literature review of the current organic NIR fluorescent probes tested in the light of human oncology and to introduce fluorescence imaging as a valuable asset in veterinary oncology.
机译：一位在肿瘤外科的主要挑战是tumoural对健康组织的术歧视。直到今天，医生依靠目视检查和触诊手术过程中定义tumoural利润，不幸的是，各种癌症类型，局部复发率从而保持高得无法接受。近红外（NIR）荧光成像是一种光学成像技术，其可以在荧光探针的给药后提供实时术前，术中的信息发射NIR光一旦暴露于NIR光源。这项技术是安全的，符合成本效益和技术上容易。目前几种近红外荧光探针研究其突出的肿瘤细胞的能力。此外，近红外荧光成像适用于前哨淋巴结映射很大的希望。这个手稿的目的是提供一种在人类肿瘤的光检测的电流有机NIR荧光探针的文献综述和引入荧光成像作为兽医肿瘤学一笔宝贵的财富。

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