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首页> 外文期刊>Current opinion in HIV and AIDS >Update on mucosal HIV vaccine vectors.
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Update on mucosal HIV vaccine vectors.

机译：关于粘膜HIV疫苗载体的更新。

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摘要

PURPOSE OF REVIEW: HIV's primary site of infection is at mucosal surfaces. To successfully defend against sexually transmitted diseases (STDs), including HIV, protection may need to be specifically elicited at the mucosal interface, where the organism enters the host. Recent advances in measuring adaptive responses at mucosal sites and optimization of techniques for low-dose repeated mucosal challenge in nonhuman primate animal models allow more in depth studies of mucosal vaccine vectors. RECENT FINDINGS: Although parenterally administered vaccines can elicit responses at mucosal sites, vaccination of mucosal sites is being explored in an attempt to increase the frequency, strength and distribution of the adaptive mucosal response. Recent studies in nonhuman primates involve vaccination of the gastrointestinal tract and rectum, as well as the nose, oropharynx or respiratory tree in an attempt to elicit responses at the distal mucosal sites where HIV transmission occurs, the rectum and genital tract. SUMMARY: Recent experiments in nonhuman primates indicate that vaccination at mucosal sites can elicit robust responses in the periphery and at mucosal sites, although the response pattern varies widely by route and regimen used. For most regimens, disease course after challenge did not differ by route of vaccination.
机译：审查目的：HIV的主要感染部位是在粘膜表面。为了成功防御包括HIV在内的性传播疾病（STD），可能需要在生物体进入宿主的粘膜界面上进行专门的保护。在非人灵长类动物模型中测量粘膜部位适应性反应和优化低剂量重复性粘膜攻击技术的最新进展，使得对粘膜疫苗载体的研究更加深入。最近的发现：尽管肠胃外施用的疫苗可以在粘膜部位引起反应，但是人们正在探索对粘膜部位进行疫苗接种，以试图提高适应性粘膜反应的频率，强度和分布。非人类灵长类动物的最新研究包括胃肠道和直肠以及鼻子，口咽或呼吸道树的疫苗接种，以试图在发生艾滋病毒传播的远端粘膜部位，直肠和生殖道引起反应。摘要：最近在非人类灵长类动物中进行的实验表明，在粘膜部位进行疫苗接种可以在外周和粘膜部位引发强烈的反应，尽管响应方式因所用途径和方案而异。对于大多数方案，激发后疾病的进程因疫苗接种途径而无差异。

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