• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in internal medicine >Update on viral hepatitis: 2007.(Miscellaneous)
【24h】

Update on viral hepatitis: 2007.(Miscellaneous)

机译：病毒性肝炎最新资料：2007年。（其他）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose of review: This is a concise review of recent developments in the field of viral hepatitis, based on publications between December 2006 and November 2007.Recent findings: Hepatitis A vaccine has similar efficacy to immune globulin as postexposure prophylaxis. Entecavir is a potent antiviral agent with a low rate of drug resistance in nucleoside-naive chronic hepatitis B patients but it is not as effective in lamivudine-refractory patients. A combination of adefovir and lamivudine is preferred to adefovir monotherapy for lamivudine-refractory hepatitis B patients. Two orally administered hepatitis C protease inhibitors, telaprevir and boceprevir, were shown to have antiviral activity in hepatitis C genotype 1 patients. A 16-week course of pegylated interferon and ribavirin resulted in a lower rate of sustained virologic response compared with the standard 24-week course. Patients with hepatitis C-related cirrhosis who achieved sustained virologic response to antiviral therapy remain at risk for hepatocellular carcinoma. A novel recombinant hepatitis E vaccine was shown to be safe and effective in preventing infection.Summary: Advances have been made in the prevention of hepatitis A and hepatitis E. It is likely that specifically targeted antiviral therapies for hepatitis C will be available in the next few years.
机译：审查目的：这是对病毒性肝炎领域近期发展的简要综述，基于2006年12月至2007年11月之间的出版物。最新发现：甲型肝炎疫苗的有效性与免疫球蛋白相似，可预防暴露后。恩替卡韦是一种有效的抗病毒药，对未接受过核苷治疗的慢性乙型肝炎患者的耐药率较低，但对拉米夫定难治性患者却无效。对于拉米夫定难治性乙型肝炎患者，阿德福韦和拉米夫定的联合治疗优于阿德福韦单药治疗。两种口服丙型肝炎蛋白酶抑制剂telaprevir和boceprevir在丙型肝炎基因1型患者中显示出抗病毒活性。与标准的24周疗程相比，聚乙二醇化干扰素和病毒唑的16周疗程导致持续的病毒学应答率降低。对抗病毒治疗获得持续病毒学应答的丙型肝炎相关性肝硬化患者仍然有患肝细胞癌的风险。新型重组戊型肝炎疫苗显示出预防感染的安全性和有效性。概述：在预防甲型肝炎和戊型肝炎方面已经取得了进展。很可能在下一个可用的针对丙型肝炎的针对性抗病毒疗法几年。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号