• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in internal medicine >Nephrogenic systemic fibrosis: epidemiology update.(Miscellaneous)
【24h】

Nephrogenic systemic fibrosis: epidemiology update.(Miscellaneous)

机译：肾源性系统性纤维化：流行病学更新。（其他）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose of review: The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence.Recent findings: Epidemiological and histochemical studies demonstrated that gadolinium-containing contrast agents used for magnetic resonance imaging have an essential causative role in most, if not all, cases of nephrogenic systemic fibrosis. One particular agent, gadodiamide, caused the majority of cases, but gadopentetate dimeglumine has also been implicated in several cases. Increasingly poor renal function, aberrations in calcium-phosphate metabolism and erythropoietin treatment seem to increase the risk of the disease and its severity. Up to 25-30% of patients with renal failure exposed to gadolinium-based contrast agents may develop nephrogenic systemic disease. The figure varies with type of gadolinium-based contrast agent and patient characteristics. There is no established curative treatment of the disease, but rapid recovery of renal function or hastened kidney transplantation may be beneficial.Summary: It is mandatory to avoid exposing patients with renal failure to gadodiamide and gadopentetate dimeglumine. Other linear gadolinium-based contrast agents should be used with great caution. It is premature to conclude whether cyclic gadolinium-based contrast agents are totally safe in renal failure.
机译：审查目的：本文旨在概述肾源性系统性纤维化的病史，这是一种新的严重的肾衰竭患者疾病，并对其病因和患病率进行了更新。最近的发现：流行病学和组织化学研究表明：用于磁共振成像的含lin造影剂在大多数（即使不是全部）肾原性系统性纤维化病例中也起着至关重要的作用。多数情况是一种特殊的药物，加多巴胺引起，但也有几例牵涉了pent戊二酸二丁胺。肾功能越来越差，磷酸钙代谢异常和促红细胞生成素治疗似乎增加了该疾病的风险及其严重程度。暴露于g基造影剂的肾衰竭患者中，多达25-30％可能会发展为肾源性全身性疾病。该数字随基于contrast的造影剂类型和患者特征而变化。目前尚无治愈该病的方法，但快速恢复肾功能或加快肾脏移植可能是有益的。总结：必须避免将患有肾功能衰竭的患者暴露于gadodiamide和gadopentetate dimeglumine中。应谨慎使用其他线性linear基造影剂。现在断定基于环g的造影剂在肾衰竭中是否完全安全还为时过早。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号