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首页> 外文期刊>Current opinion in lipidology >Hyperelongated biglycan: the surreptitious initiator of atherosclerosis.
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Hyperelongated biglycan: the surreptitious initiator of atherosclerosis.

机译：过度伸长的双链聚糖：动脉粥样硬化的秘密发起者。

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PURPOSE OF REVIEW: To outline a role for the dermatan sulfate proteoglycan biglycan and specifically its growth factor modified form having elongated glycosaminoglycan chains as being a primary initiator of atherosclerosis. RECENT FINDINGS: Antiatherosclerotic therapies have mostly targeted epidemiologically identified, experimentally confirmed risk factors. The efficacy of such therapies is less than optimal, and rates of cardiovascular disease remain stubbornly high. A variety of targets have been actively pursued, but as yet no new therapy has emerged that specifically targets the vessel wall. One area concerns the role of proteoglycans in the trapping of atherogenic lipoproteins as an early and initiating step in atherogenesis. On the basis of studies in human coronary arteries, the prime proteoglycan for lipoprotein retention is biglycan. The glycosaminoglycan chains on biglycan are subject to regulation that yields several structural changes, but most prominently elongation of the chains to form 'hyperelongated biglycan'. Multiple animal studies and a recent human disorder study have demonstrated the colocalization of atherogenic lipoproteins with biglycan in atherosclerotic lesions. Moreover, in the human atherosclerosis, the deposition of lipid appears to precede the chronic inflammatory response typical of atherosclerotic lesions. SUMMARY: The process of biglycan-associated glycosaminoglycan elongation represents a novel potential therapeutic target worthy of full investigation for the prevention of atherosclerosis.
机译：审查的目的：概述硫酸皮肤素蛋白聚糖双糖聚糖的作用，特别是其具有延长的糖胺聚糖链的生长因子修饰形式，作为动脉粥样硬化的主要起因。最近的发现：抗动脉粥样硬化疗法主要针对流行病学上确定的，实验确定的危险因素。这样的疗法的疗效不是最佳的，并且心血管疾病的发生率仍然顽固地很高。已经积极地追求了多种目标，但是至今还没有出现专门针对血管壁的新疗法。一个领域涉及蛋白聚糖在动脉粥样硬化形成的早期和起始步骤中在动脉粥样硬化性脂蛋白的捕获中的作用。根据对人类冠状动脉的研究，脂蛋白保留的主要蛋白聚糖是双糖链蛋白聚糖。双链蛋白聚糖上的糖胺聚糖链受到调节，产生一些结构变化，但最显着的是链的延长以形成“超长双链蛋白聚糖”。多项动物研究和一项最近的人类疾病研究表明，动脉粥样硬化病变中动脉粥样硬化脂蛋白与双链糖蛋白的共定位。此外，在人的动脉粥样硬化中，脂质的沉积似乎先于动脉粥样硬化病变的典型慢性炎症反应。摘要：与糖链蛋白相关的糖胺聚糖的延伸过程代表了一种新型的潜在治疗靶标，值得进行全面研究以预防动脉粥样硬化。

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