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首页> 外文期刊>Current opinion in lipidology >Ambivalence of progenitor cells in vascular repair and plaque stability.
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Ambivalence of progenitor cells in vascular repair and plaque stability.

机译：祖细胞在血管修复和斑块稳定性方面的矛盾性。

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PURPOSE OF REVIEW: To discuss crucial cues (chemokines, adhesion molecules and pharmacological means) that guide and control the context-specific mobilization, recruitment and fate of circulating progenitor cells in arterial repair and plaque stability. RECENT FINDINGS: The mobilization and recruitment of bone marrow derived or resident progenitor cells giving rise to smooth muscle cells have been implicated in accelerated forms of primary plaque formation and neointimal hyperplasia after arterial injury. By contrast, convincing evidence has emerged that the arterial homing of endothelial progenitor cells contributes to endothelial recovery and thereby limits neointimal growth after endothelial denudation. In the chronic context of primary atherosclerosis, plaque progression and destabilization, a more complex picture has become apparent. Clinically, the number and function of endothelial progenitor cells have been linked with an improved endothelial function or regeneration and have been frequently inversely correlated with cardiovascular risk (factors). In animal models, however, the injection of bone marrow cells or endothelial progenitor cells, as well as the application of stem-cell mobilizing factors, have been associated with an exacerbation of atherosclerosis and unstable plaque phenotype, whereas the contribution of smooth muscle progenitors to primary atherosclerosis appears to be more confined to supporting plaque stability. SUMMARY: Considering the balance between distinct circulating vascular progenitor cells and identifying mechanisms for selective control of their mobilization and homing appears crucial to improve prediction and to directly modulate endogenous vascular remodeling processes.
机译：审查目的：讨论关键线索（趋化因子，粘附分子和药理手段），这些线索指导和控制循环祖细胞在动脉修复和斑块稳定性方面的背景特定动员，募集和命运。最近的发现：动员和募集产生平滑肌细胞的骨髓来源或固有祖细胞与动脉损伤后原发性斑块形成和新内膜增生的加速形式有关。相比之下，令人信服的证据已经出现，内皮祖细胞的动脉归巢有助于内皮的恢复，从而限制了内皮剥脱后新内膜的生长。在原发性动脉粥样硬化，斑块进展和不稳定的慢性背景下，更为复杂的情况已变得显而易见。在临床上，内皮祖细胞的数量和功能与改善的内皮功能或再生有关，并且经常与心血管风险（因素）成反比。然而，在动物模型中，骨髓细胞或内皮祖细胞的注射以及干细胞动员因子的应用与动脉粥样硬化和不稳定斑块表型的恶化有关，而平滑肌祖细胞对原发性动脉粥样硬化似乎更局限于支持斑块稳定性。摘要：考虑到不同的循环血管祖细胞之间的平衡，并确定选择性控制其动员和归巢的机制，对于改善预测和直接调节内源性血管重塑过程似乎至关重要。

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