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首页> 外文期刊>Current opinion in lipidology >Oxidized phospholipids: emerging lipid mediators in pathophysiology.
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Oxidized phospholipids: emerging lipid mediators in pathophysiology.

机译：氧化磷脂：病理生理中新兴的脂质介体。

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PURPOSE OF REVIEW: Oxidized phospholipids are biologically active agents that are generated by lipid peroxidation. They are associated with inflammation, oxidative stress and several diseased states as described by an increasing number of reports. In addition, information about the interaction partners, the binding sites, the intracellular signalling and the metabolizing enzymes of these compounds is rapidly increasing. This review will briefly summarize recent findings and focus on mechanisms with potential pathophysiological relevance. RECENT FINDINGS: Reports reviewed here provide interesting insights into the involvement of oxidized phospholipids in interleukin transcription, phenotype switching of smooth muscle cells and apoptotic mechanisms of the modified phospholipids as well as the identification of metabolizing enzymes. SUMMARY: Recent studies shed some light on oxidized phospholipid-induced signalling with regard to apoptosis, gene expression and receptor-mediated events. They support the notion that the bioactivities of these natural agents detrimentally contribute to the pathological alteration of basic mechanisms to states recognized in numerous medical conditions. Advances in the knowledge of signalling pathways and interaction partners of oxidized phospholipids will increase our understanding of inflammatory processes and molecular mechanisms of various diseases including atherosclerosis and may play an important role in the development of future therapeutic options or diagnostics.
机译：审查目的：氧化的磷脂是由脂质过氧化作用产生的生物活性剂。如越来越多的报道所述，它们与炎症，氧化应激和几种疾病状态有关。另外，关于这些化合物的相互作用伴侣，结合位点，细胞内信号传导和代谢酶的信息正在迅速增加。这篇综述将简要总结最近的发现，并将重点放在具有潜在病理生理相关性的机制上。最近的发现：此处审查的报告提供了关于氧化磷脂参与白介素转录，平滑肌细胞表型转换和修饰磷脂的凋亡机制以及鉴定代谢酶的有趣见解。简介：最近的研究为细胞凋亡，基因表达和受体介导的事件对氧化磷脂诱导的信号传导提供了一些启示。他们支持这样的观点，即这些天然药物的生物活性有害地促进了基本机制向许多医学状况下公认的状态的病理改变。氧化磷脂的信号通路和相互作用伙伴的知识的进步将增加我们对各种疾病（包括动脉粥样硬化）的炎症过程和分子机制的了解，并且可能在未来治疗方案或诊断方法的开发中发挥重要作用。

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