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首页> 外文期刊>Current opinion in lipidology >Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism.
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Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism.

机译：微粒甘油三酸酯在血浆和细胞脂质代谢中转移蛋白。

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摘要

PURPOSE OF REVIEW: This review summarizes recent advances about the role of microsomal triglyceride transfer protein in plasma and tissue lipid homeostasis. RECENT FINDINGS: Microsomal triglyceride transfer protein emerged as a phospholipid transfer protein and acquired triacylglycerol transfer activity during evolution from invertebrates to vertebrates. These activities are proposed to participate in 'nucleation' and 'desorption' steps during the biosynthesis of primordial apoB-containing lipoproteins. Microsomal triglyceride transfer protein also transfers phospholipids to the glycolipid antigen presentation molecule CD1d. Under physiologic conditions, plasma apoB-containing lipoproteins and microsomal triglyceride transfer protein expression exhibit diurnal variations synchronized by food and light. Microsomal triglyceride transfer protein is regulated at the transcriptional level. HNF4alpha is critical for its transcription. Other transcription factors along with coactivators and corepressors modulate microsomal triglyceride transfer protein expression. Reductions in microsomal triglyceride transfer protein mRNA and activity are related to steatosis in HCV-3 infected patients. CCl4 induces steatosis by enhancing proteasomal degradation of microsomal triglyceride transfer protein and can be partially avoided by inhibiting this degradation. Chemical antagonists cause hepatosteatosis, but this was not seen in the absence of fatty acid binding protein. SUMMARY: Microsomal triglyceride transfer protein is a target to lower plasma lipids and to reduce inflammation in certain immune disorders. More knowledge is required, however, regarding its regulation and its role in the biosynthesis of apoB-containing lipoproteins and CD1d.
机译：综述的目的：这篇综述总结了微粒体甘油三酸酯转移蛋白在血浆和组织脂质稳态中的作用的最新进展。最近的发现：微粒体甘油三酸酯转移蛋白以磷脂转移蛋白的形式出现，并在从无脊椎动物进化到脊椎动物的过程中获得了三酰基甘油转移活性。这些活性被提议参与原始apoB含脂蛋白的生物合成过程中的“成核”和“解吸”步骤。微粒体甘油三酸酯转移蛋白还将磷脂转移到糖脂抗原呈递分子CD1d。在生理条件下，血浆含载脂蛋白B的脂蛋白和微粒体甘油三酸酯转移蛋白的表达表现出与食物和光照同步的昼夜变化。微粒体甘油三酸酯转移蛋白在转录水平受到调控。 HNF4alpha对于其转录至关重要。其他转录因子与共激活因子和共抑制因子一起调节微粒体甘油三酸酯转移蛋白的表达。微粒体甘油三酸酯转移蛋白mRNA和活性的降低与HCV-3感染患者的脂肪变性有关。 CCl4通过增强微粒体甘油三酸酯转移蛋白的蛋白酶体降解来诱导脂肪变性，并且可以通过抑制这种降解来部分避免。化学拮抗剂可引起肝脂肪变性，但在缺乏脂肪酸结合蛋白的情况下未见到。摘要：微粒体甘油三酸酯转移蛋白是降低血浆脂质和减少某些免疫疾病中炎症的靶标。但是，关于其调控及其在含apoB的脂蛋白和CD1d的生物合成中的作用，需要更多的知识。

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