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首页> 外文期刊>Current opinion in lipidology >Paraoxonase 1 activity, concentration and genotype in cardiovascular disease.
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Paraoxonase 1 activity, concentration and genotype in cardiovascular disease.

机译：对氧磷酶1的活性，浓度和基因型在心血管疾病中。

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摘要

PURPOSE OF REVIEW: To provide up-to-date information on the most recent advances in the epidemiology, biochemistry and molecular biology of the antiatherosclerotic enzyme paraoxonase 1. RECENT FINDINGS: Case-control and prospective studies published during the period covered by this review have indicated that paraoxonase 1 'status' (i.e. activity and/or concentration) was a more important coronary heart disease risk factor than the paraoxonase 1 genetic polymorphisms. New findings on the role of paraoxonase 1 in homocysteine metabolism are reviewed, as are advances in the nutritional and pharmacological regulation of paraoxonase 1. The recent controversy over whether paraoxonase 1 or platelet-activating factor acetylhydrolase is responsible for the antioxidant activity of high-density lipoprotein is also addressed. SUMMARY: In the light of recent findings, we believe that genetic epidemiological studies of the paraoxonase 1 polymorphisms in relation to coronary heart disease should no longer be undertaken unless they are very large and prospective in nature. More research should be undertaken to discover the biochemical mechanisms underlying the mode of action of paraoxonase 1 and the factors which modulate its activity and/or concentration. SPONSORSHIP: Bharti Mackness is funded by the International HDL Research Awards Programme. All authors receive research funding from the British Heart Foundation and Diabetes UK.
机译：审查目的：提供有关抗动脉粥样硬化酶对氧磷酶1的流行病学，生物化学和分子生物学的最新进展的最新信息。最新发现：在本报告所述期间，病例对照和前瞻性研究已经发表。指出对氧磷酶1的“状态”（即活性和/或浓度）是比对氧磷酶1的遗传多态性更重要的冠心病危险因素。综述了对氧磷酶1在同型半胱氨酸代谢中的作用的新发现，以及对氧磷酶1在营养和药理学调节方面的进展。最近有关对氧磷酶1或血小板活化因子乙酰水解酶是否负责高密度抗氧化活性的争论脂蛋白也得到解决。摘要：根据最近的发现，我们认为对氧磷酶1多态性与冠心病有关的遗传流行病学研究应不再进行，除非它们的性质非常大且具有前瞻性。应该进行更多的研究以发现对氧磷酶1作用方式的潜在生化机制以及调节其活性和/或浓度的因素。赞助：Bharti Mackness由国际HDL研究奖计划资助。所有作者均从英国心脏基金会和英国糖尿病学会获得研究经费。

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