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首页> 外文期刊>Current opinion in lipidology >Genetics and molecular biology: brain cholesterol balance--not such a closed circuit after all.
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Genetics and molecular biology: brain cholesterol balance--not such a closed circuit after all.

机译：遗传学和分子生物学：大脑胆固醇的平衡-毕竟不是闭环的。

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Over 60% of the brain dry weight is lipid, with cholesterol being the single most abundant lipid species. Cholesterol is required for instance for myelination [1] and synapto-genesis [2]. Normally, plasmacholesterol is not taken up by the central nervous systenr(CNS) as the blood-brain barrier (BBB) prevents the diffusion of large molecules at the level of tight junctions between brain capillary endo-thelial cells [3]. The ±>ulk of the brain cholesterol is synthesized within the CNS [3] and eliminated across the BBB mainly through conversion into 24(S)-hydroxy-cholesterol [4]. Astrocytes, the most abundant cell type in the CNS, synthesize and secrete cholesterol in apolipo-protein E (apoE) containing lipoprotein particles, and an astrocyte-neuron cholesterol 'shuttle' has been suggested [2], where mature neurons rely on cholesterol produced by astrocytes.
机译：脑干重的60％以上是脂质，胆固醇是唯一最丰富的脂质种类。胆固醇例如对于髓鞘化[1]和突触形成[2]是必需的。正常情况下，血浆胆固醇不会被中枢神经系统（CNS）吸收，因为血脑屏障（BBB）阻止了大分子在脑毛细血管内皮细胞之间紧密连接处的扩散[3]。脑胆固醇的±> ulk在CNS中合成[3]，并主要通过转化为24（S）-羟基胆固醇[4]而在整个BBB中消除。星形胶质细胞是中枢神经系统中最丰富的细胞类型，它合成并分泌含脂蛋白E（apoE）的脂蛋白颗粒中的胆固醇，并且已经提出了星形胶质细胞-神经元的胆固醇“穿梭” [2]，其中成熟的神经元依赖于产生的胆固醇通过星形胶质细胞。

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