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Nutrition and metabolism: new studies of the effects of diets and exercise on lipid and lipoprotein metabolism.

机译:营养与代谢:饮食和运动对脂质和脂蛋白代谢影响的新研究。

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摘要

Obesity portends diabetes • and cardiovascular disease (GVD). Dyslipoproteinemia, reflected by elevated plasma triglyceride and reduced HDL concentrations, is a cardinal feature of obesity that independently predicts CVD and is accordingly a therapeutic target for risk reduction. Dysregulation of lipopsotein metabolism may be caused by a combination of overproduction of VLDL-apolipo-protein (apo) B-100, decreased catabolism of apoB-containing particles, and increased catabolism of HDL apoA-I particles [1*,2*]. Nutrition and exercise play important roles in regulating lipid and lipoprotein metabolism. Understanding the dynamic mechanisms in vivo is important.
机译:肥胖预示着糖尿病和心血管疾病(GVD)。血浆甘油三酸酯升高和HDL浓度降低反映出的脂蛋白异常是肥胖症的主要特征,其独立预测CVD,因此是降低风险的治疗目标。脂质脂蛋白代谢的失调可能是由于VLDL-载脂蛋白(apo)B-100的过量生产,含apoB颗粒的分解代谢降低和HDL apoA-I颗粒的分解代谢增加[1 *,2 *]引起的。营养和运动在调节脂质和脂蛋白代谢中起重要作用。了解体内的动力学机制很重要。

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