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首页> 外文期刊>Current opinion in lipidology >The lipolysis stimulated receptor: a gene at last.
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The lipolysis stimulated receptor: a gene at last.

机译：脂解刺激受体：最后一个基因。

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摘要

The lipolysis stimulated receptor is a lipoprotein receptor that was initially described in 1992. In the presence of free fatty acids, the lipolysis stimulated receptor recognizes either apolipoprotein B or apolipoprotein E, and as a consequence, leads to the internalization and degradation of the lipoprotein particles. Its affinity is highest for those lipoproteins most susceptible to lipolysis, triglyceride-rich lipoproteins. Since the initial biochemical identification and description of the lipolysis stimulated receptor, several reports have been published by our group that provide circumstantial evidence for its role in vivo for the clearance of triglyceride-rich lipid particles. In this review, we bring the readers up-to-date on the evidence for the role of the lipolysis stimulated receptor in lipoprotein metabolism, as well as the recent developments in its molecular characterization.
机译：脂解刺激受体是一种脂蛋白受体，最初描述于1992年。在存在游离脂肪酸的情况下，脂解刺激受体识别载脂蛋白B或载脂蛋白E，因此导致脂蛋白颗粒的内在化和降解。对于最容易脂解的那些脂蛋白，富含甘油三酸酯的脂蛋白，其亲和力最高。自从最初的生化鉴定和脂解刺激受体的描述以来，我们的小组已发表了几份报告，提供了其在体内清除富含甘油三酸酯的脂质颗粒中的作用的间接证据。在这篇综述中，我们使读者了解脂解刺激受体在脂蛋白代谢中的作用以及其分子表征的最新进展。

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