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Life and death in the atherosclerotic plaque.

机译：生与死在动脉粥样硬化斑块中。

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PURPOSE OF REVIEW: Changes in cell mass in atherosclerosis represent changes in cell division, cell death and migration/emigration, all of which may be occurring simultaneously in different cell types at different times and in different regions of the plaque. This makes measurement of these individual processes and measurement of overall cell kinetics in atherosclerosis difficult, with the challenges and shortfalls only recently becoming apparent. This review will outline the problems associated with assaying cell proliferation and cell death, and how these processes relate to changes in overall cell kinetics and measurement of biological age. RECENT FINDINGS: Cell division and cell death have historically been assayed as frequencies of specific processes, with at times ill-defined and nonspecific markers. More recent studies have moved towards cumulative assays that can measure overall rates over time, resulting in a 'biological' age or replication history of a tissue or cell. SUMMARY: The complexity of processes involved in assaying changes in cell kinetics in atherosclerosis mean that we must move towards cumulative assays of cell proliferation, cell death and senescence that can be measured in the time frames over which atherosclerosis occurs, and for studies that selectively manipulate one of these processes in a single-cell type without affecting other processes.
机译：审查目的：动脉粥样硬化中细胞量的变化代表细胞分裂，细胞死亡和迁移/迁移的变化，所有这些可能同时发生在不同时间，不同斑块的不同细胞类型中。这使得这些个体过程的测量和动脉粥样硬化中整个细胞动力学的测量变得困难，挑战和不足直到最近才显现出来。这篇综述将概述与测定细胞增殖和细胞死亡有关的问题，以及这些过程与总体细胞动力学变化和生物年龄测量之间的关系。最近的发现：细胞分裂和细胞死亡历来被分析为特定过程的频率，有时带有不确定的和非特异性的标记。最近的研究已经朝着累积测定法发展，该测定法可以随着时间的推移测量总体速率，从而导致组织或细胞的“生物学”年龄或复制历史。简介：分析动脉粥样硬化细胞动力学变化所涉及的过程非常复杂，这意味着我们必须朝着可以在发生动脉粥样硬化的时间范围内进行测量的细胞增殖，细胞死亡和衰老进行累积分析，以及进行选择性操纵的研究单细胞类型中的这些过程之一，而不会影响其他过程。

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