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首页> 外文期刊>Current opinion in lipidology >Adverse metabolic effects of dietary fructose: Results from the recent epidemiological, clinical, and mechanistic studies
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Adverse metabolic effects of dietary fructose: Results from the recent epidemiological, clinical, and mechanistic studies

机译：饮食中果糖的不良代谢作用：最新流行病学，临床和机制研究的结果

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Purpose of review The effects of dietary sugar on risk factors and the processes associated with metabolic disease remain a controversial topic, with recent reviews of the available evidence arriving at widely discrepant conclusions. Recent findings There are many recently published epidemiological studies that provide evidence that sugar consumption is associated with metabolic disease. Three recent clinical studies, which investigated the effects of consuming relevant doses of sucrose or high-fructose corn syrup along with ad libitum diets, provide evidence that consumption of these sugars increase the risk factors for cardiovascular disease and metabolic syndrome. Mechanistic studies suggest that these effects result from the rapid hepatic metabolism of fructose catalyzed by fructokinase C, which generates substrate for de novo lipogenesis and leads to increased uric acid levels. Recent clinical studies investigating the effects of consuming less sugar, via educational interventions or by substitution of sugar-sweetened beverages for noncalorically sweetened beverages, provide evidence that such strategies have beneficial effects on risk factors for metabolic disease or on BMI in children. Summary The accumulating epidemiological evidence, direct clinical evidence, and the evidence suggesting plausible mechanisms support a role for sugar in the epidemics of metabolic syndrome, cardiovascular disease, and type 2 diabetes.
机译：审查目的饮食糖对危险因素和与代谢疾病相关的过程的影响仍然是一个有争议的话题，最近对现有证据的审查得出了截然不同的结论。最近的发现最近有许多流行病学研究提供证据，证明糖的消耗与代谢性疾病有关。最近的三项临床研究调查了食用任意剂量的蔗糖或高果糖玉米糖浆以及随意饮食的影响，这些证据表明食用这些糖会增加心血管疾病和代谢综合征的危险因素。机理研究表明，这些作用是由果糖激酶C催化的果糖快速肝代谢引起的，果糖激酶C产生了新生脂肪形成的底物并导致尿酸水平升高。最近的临床研究调查了通过教育干预或用含糖饮料代替无热量甜味饮料来减少糖摄入量的影响，这些证据提供了这种策略对儿童代谢性疾病或BMI的危险因素具有有益作用的证据。总结流行病学证据，直接临床证据以及表明合理机制的证据支持糖在代谢综合征，心血管疾病和2型糖尿病的流行中发挥作用。

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