...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in lipidology >Thrombospondins: Old players, new games
【24h】

Thrombospondins: Old players, new games

机译：血小板反应蛋白：老玩家，新游戏

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE OF REVIEW: Thrombospondins (TSPs) are secreted extracellular matrix (ECM) proteins from TSP family, which consists of five homologous members. They share a complex domain structure and have numerous binding partners in ECM and multiple cell surface receptors. Information that has emerged over the past decade identifies TSPs as important mediators of cellular homeostasis, assigning new important roles in cardiovascular pathology to these proteins. RECENT FINDINGS: Recent studies of the functions of TSP in the cardiovascular system, diabetes and aging, which placed several TSPs in a position of critical regulators, demonstrated the involvement of these proteins in practically every aspect of cardiovascular pathophysiology related to atherosclerosis: inflammation, immunity, leukocyte recruitment and function, function of vascular cells, angiogenesis, and responses to hypoxia, ischemia and hyperglycemia. TSPs are also critically important in the development and ultimate outcome of the complications associated with atherosclerosis - myocardial infarction, and heart hypertrophy and failure. Their expression and significance increase with age and with the progression of diabetes, two major contributors to the development of atherosclerosis and its complications. SUMMARY: This overview of recent literature examines the latest information on the newfound functions of TSPs that emphasize the importance of ECM in cardiovascular homeostasis and pathology. The functions of TSPs in myocardium, vasculature, vascular complications of diabetes, aging and immunity are discussed.
机译：审查目的：血小板反应蛋白（TSPs）是TSP家族分泌的细胞外基质（ECM）蛋白，由5个同源成员组成。它们共享复杂的结构域结构，在ECM和多种细胞表面受体中具有众多结合伴侣。过去十年中出现的信息将TSPs确定为细胞稳态的重要介体，从而在这些蛋白的心血管病理学中赋予了新的重要作用。最近的发现：对TSP在心血管系统，糖尿病和衰老中的功能的最新研究使几种TSP处于关键调节剂的位置，表明这些蛋白实际上参与了与动脉粥样硬化相关的心血管病理生理学的各个方面：炎症，免疫，白细胞募集和功能，血管细胞功能，血管生成以及对缺氧，局部缺血和高血糖的反应。 TSP在与动脉粥样硬化相关的并发症（心肌梗塞，心脏肥大和衰竭）的发展和最终结果中也至关重要。它们的表达和意义随着年龄的增长和糖尿病的发展而增加，这是动脉粥样硬化及其并发症发展的两个主要因素。简介：最近文献的概述检查了有关TSP的新发现功能的最新信息，这些信息强调了ECM在心血管稳态和病理学中的重要性。讨论了TSPs在心肌，脉管系统，糖尿病的血管并发症，衰老和免疫中的功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号