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首页> 外文期刊>Current opinion in lipidology >Prevention of coronary heart disease by raising high-density lipoprotein cholesterol?
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Prevention of coronary heart disease by raising high-density lipoprotein cholesterol?

机译：通过增加高密度脂蛋白胆固醇预防冠心病？

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摘要

Consistent with several potentially anti-atherogenic activities of high-density lipoproteins in vitro, low plasma levels of high-density lipoprotein cholesterol are associated with an increased risk of coronary heart disease. In addition to genes, lifestyle factors (e.g. smoking, being overweight and physical inactivity) strongly affect plasma high-density lipoprotein cholesterol levels. Moreover, a low level of high-density lipoprotein cholesterol interacts with other risk factors. Raising of high-density lipoprotein cholesterol by either adjustments of lifestyle or drug intervention as well as elimination of additional risk factors are thus thought to affect coronary risk. Here, we summarize the outcomes of observational and interventional studies as well as genetic and experimental research which have recently much advanced our understanding of the function and regulation of high-density lipoprotein metabolism. We conclude from the data that changes in the kinetics and functionality of high-density lipoprotein rather than changes in plasma high-density lipoprotein cholesterol levels per se will affect the anti-atherogenicity of therapeutic interference with high-density lipoprotein metabolism.
机译：与高密度脂蛋白在体外的几种潜在的抗动脉粥样硬化活性相一致，高密度脂蛋白胆固醇的低血浆水平与冠心病的风险增加相关。除了基因外，生活方式因素（例如吸烟，超重和缺乏体育锻炼）也会强烈影响血浆高密度脂蛋白胆固醇水平。此外，低水平的高密度脂蛋白胆固醇会与其他危险因素相互作用。因此，通过调整生活方式或药物干预以及消除其他危险因素来升高高密度脂蛋白胆固醇被认为会影响冠心病的危险。在这里，我们总结了观察性和介入性研究以及遗传和实验研究的成果，这些研究成果最近大大提高了我们对高密度脂蛋白代谢的功能和调控的理解。我们从这些数据得出结论，高密度脂蛋白的动力学和功能的变化而不是血浆高密度脂蛋白胆固醇水平的变化本身将影响高密度脂蛋白代谢的治疗干扰的抗动脉粥样硬化性。

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