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首页> 外文期刊>Current opinion in lipidology >Early initiation of statin therapy after a coronary event.
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Early initiation of statin therapy after a coronary event.

机译：冠状动脉事件后早期开始他汀类药物治疗。

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PURPOSE OF REVIEW Despite improvements in the early management of acute coronary syndromes, the risk of major cardiovascular complications remains high. Lipid-modifying treatment with statins has the potential to further improve outcomes through improved endothelial function, antithrombotic and antiinflammatory actions. Statins are of proven benefit in patients with stable coronary heart disease. There has been speculation on potential mechanisms of benefit but, until recently, little data on the efficacy and safety of statins in the acute setting. Recent observational studies and randomized trials have addressed some of the questions regarding early initiation of statins in acute coronary syndromes.RECENT FINDINGS Recent observational and randomized trials have shown that early commencement of statins in acute coronary syndromes is safe as early as 6 hours after the event and is likely to improve longer-term compliance. The current data are not sufficient to draw conclusions about the efficacy of statins early in the course of acute coronary syndromes.SUMMARY Current management for acute coronary syndromes should include the commencement of statin therapy during initial hospital admission. This recommendation is based on safety and compliance data. More randomized trial evidence is required to determine whether early initiation will produce better outcomes than later initiation after an acute coronary event.
机译：回顾的目的尽管急性冠脉综合征的早期治疗有所改善，但发生重大心血管并发症的风险仍然很高。他汀类药物的脂质修饰疗法具有通过改善内皮功能，抗血栓形成和抗炎作用进一步改善预后的潜力。他汀类药物在稳定的冠心病患者中被证明具有益处。人们一直在猜测其潜在的获益机制，但直到最近，有关他汀类药物在急性环境中的功效和安全性的数据还很少。最近的观察性研究和随机试验已解决了有关急性冠状动脉综合征中他汀类药物的早期启动的一些问题。最近的观察和随机试验表明，急性冠状动脉综合征中他汀类药物的早期启动在事件发生后的6小时内是安全的。并有可能改善长期合规性。目前的数据不足以得出他汀类药物在急性冠脉综合征早期的疗效结论。总结急性冠脉综合征的当前管理应包括在首次住院期间开始他汀类药物治疗。此建议基于安全性和合规性数据。需要更多随机试验证据来确定在急性冠状动脉事件后，早期开始是否比晚期开始产生更好的结果。

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