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首页> 外文期刊>Current opinion in lipidology >Effect of high-density lipoproteins on the expression of adhesion molecules in endothelial cells.
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Effect of high-density lipoproteins on the expression of adhesion molecules in endothelial cells.

机译：高密度脂蛋白对内皮细胞黏附分子表达的影响。

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摘要

There are several potential mechanisms by which HDLs protect against atherosclerosis. One relates to the ability of HDLs to promote the efflux of cholesterol from macrophages. Another is the ability of HDLs to inhibit one of the earliest events in the development of atherosclerosis, namely the expression of vascular cell adhesion molecules in activated endothelial cells. This property has been reported in vitro in studies with both native and reconstituted HDLs. The inhibitory activity of reconstituted HDLs is influenced by the phospholipid composition of the particles. An inhibition of endothelial cell adhesion molecule expression has also been observed in some (but not all) studies conducted in vivo in mice and pigs. The mechanism of this potentially anti-atherogenic effect of HDLs remains uncertain, as does its contribution to the cardioprotective effects of HDLs in vivo.
机译：HDL可以通过多种潜在机制来预防动脉粥样硬化。一个涉及HDLs促进巨噬细胞胆固醇外排的能力。另一个是HDL抑制动脉粥样硬化发展中最早事件之一的能力，即活化的内皮细胞中血管细胞粘附分子的表达。在使用天然和重组HDL进行的研究中均已报道了该特性。重构的HDL的抑制活性受颗粒的磷脂组成影响。在一些在小鼠和猪体内进行的研究（但不是全部）也观察到了内皮细胞粘附分子表达的抑制作用。 HDLs潜在的抗动脉粥样硬化作用的机制尚不清楚，其在体内对HDLs心脏保护作用的贡献也是如此。

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