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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B
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Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B

机译：乙型肝炎病毒的表观遗传调节共价闭合圆形DNA：对慢性乙型肝炎的表观遗传治疗的影响

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Hepatitis B virus (HBV) infection represents a significant public health burden worldwide. Although current therapeutics manage to control the disease progression, lifelong treatment and surveillance are required because drug resistance develops during treatment and reactivations frequently occur following medication cessation. Thus, the occurrence of hepatocellular carcinoma is decreased, but not eliminated. One major reason for failure of HBV treatment is the inability to eradicate or inactivate the viral covalently closed circular DNA (cccDNA), which is a stable episomal form of the viral genome decorated with host histones and nonhistone proteins. Accumulating evidence suggests that epigenetic modifications of cccDNA contribute to viral replication and the outcome of chronic HBV infection. Here, we summarize current progress on HBV epigenetics research and the therapeutic implications for chronic HBV infection by learning from the epigenetic therapies for cancer and other viral diseases, which may open a new venue to cure chronic hepatitis B. (Hepatology 2017;66:20662077)
机译：乙型肝炎病毒（HBV）感染是全世界的重大公共卫生负担。虽然目前的治疗方法可以控制疾病进展，但需要终身治疗和监测，因为在治疗期间发生耐药性和抗药性，常常发生药物治疗。因此，肝细胞癌的发生降低，但未被消除。 HBV治疗失败的一个主要原因是无法消除或灭活病毒共价闭合的圆形DNA（CCCDNA），其是用宿主组蛋白和非母蛋白装饰的病毒基因组的稳定的再生形式。积累证据表明CCCDNA对病毒复制的表观遗传修复以及慢性HBV感染的结果。在这里，我们通过从癌症和其他病毒疾病的表观遗传疗法学习，总结了HBV表观生物学研究的目前对慢性HBV感染的治疗影响，这可能开辟了治愈慢性乙型肝炎的新场所（肝脏2017; 66：20662077 ）

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