...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Inactivated and live, attenuated influenza vaccines protect mice against influenza: Streptococcus pyogenes super-infections
【24h】

Inactivated and live, attenuated influenza vaccines protect mice against influenza: Streptococcus pyogenes super-infections

机译：灭活和活化，减毒的流感疫苗保护小鼠免受流感：链球菌Pyogenes超级感染

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mortality associated with influenza virus super-infections is frequently due to secondary bacterial complications. To date, super-infections with Streptococcus pyogenes have been studied less extensively than those associated with Streptococcus pneumoniae. This is significant because a vaccine for S. pyogenes is not clinically available, leaving vaccination against influenza virus as our only means for preventing these super-infections. In this study, we directly compared immunity induced by two types of influenza vaccine, either inactivated influenza virus (IIV) or live, attenuated influenza virus (LAIV), for the ability to prevent super-infections. Our data demonstrate that both IIV and LAIV vaccines induce similar levels of serum antibodies, and that LAIV alone induces IgA expression at mucosal surfaces. Upon superinfection, both vaccines have the ability to limit the induction of pro-inflammatory cytokines within the lung, including IFN-gamma which has been shown to contribute to mortality in previous models of superinfection. Limiting expression of these pro-inflammatory cytokines within the lungs subsequently limits recruitment of macrophages and neutrophils to pulmonary surfaces, and ultimately protects both IIV- and LAIV-vaccinated mice from mortality. Despite their overall survival, both IIV- and LAIV-vaccinated mice demonstrated levels of bacteria within the lung tissue that are similar to those seen in unvaccinated mice. Thus, influenza virus:bacteria super-infections can be limited by vaccine-induced immunity against influenza virus, but the ability to prevent morbidity is not complete
机译：与流感病毒超级感染相关的死亡率通常是由于继发性细菌并发症。迄今为止，已经过度地研究了与链球菌肺炎链球菌相关的链球菌化合物的超级感染。这是显着的，因为在临床上没有临床可用的疫苗，留下对流感病毒的疫苗接种，因为我们唯一用于预防这些超感染的手段。在这项研究中，我们直接比较了两种类型的流感疫苗，灭活流感病毒（IIV）或活化，减毒的流感病毒（Laiv）的免疫力，以防止超级感染。我们的数据表明，IIV和LaIV疫苗均诱导类似水平的血清抗体，并仅仅诱导粘膜表面的IgA表达。在SuperInfection后，疫苗都具有限制肺内促炎细胞因子的诱导能力，包括IFN-Gamma，其已被证明可以有助于以前的超蛋白模型中的死亡率。限制肺部内这些促炎细胞因子的表达随后将巨噬细胞和中性粒细胞的募集限制为肺表面，并最终保护IIV和Laiv疫苗的小鼠免受死亡率的影响。尽管他们整体存活，但IIV和Laiv接种疫苗的小鼠均展示了与未被解ic的小鼠中所见的肺组织内的细菌水平。因此，流感病毒：细菌超级感染可以受疫苗诱导的抗甲型病毒的免疫限制，但防止发病率的能力不完整

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号