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A survey of children's preferences for influenza vaccine attributes

机译：儿童疫苗疫苗属性偏好调查

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Background: While annual influenza vaccination is recommended by the CDC for children 6 months and older, vaccination rates remain suboptimal. For healthy, US children 2 years of age and older, influenza vaccine is available as an intramuscular injection (TIV) or an intranasal spray (LAIV), respectively. Little is known about children's experiences and preferences for influenza vaccine attributes.Objective: To examine preferences for influenza vaccine attributes and their relative importance among children.Methods: A quantitative web-survey was administered to children aged 8-12 years sampled from a standing online panel representative of the US population. Children were stratified by age, gender and parent's influenza vaccination behavior. The survey included questions to ascertain children's preferences for influenza vaccine attributes, including efficacy, chance of common side effects, and mode of administration. It included conjoint (trade-off) questions in which children traded-off different attributes in their choice between two influenza vaccines with differing features. We also surveyed children's comprehension of and ability to complete the conjoint questions.Results: 544 children completed the survey (response rate 37%). Children most frequently selected efficacy as the most important vaccine attribute followed by mode of administration (45% and 31%, respectively). When asked for their preference to receive influenza vaccine as a "shot" or a "nose spray", the majority (69%) preferred the nose spray. An evaluation of children's ability to complete the conjoint survey demonstrated that 85% of the sample was able to complete the conjoint tasks. Analysis of the conjoint responses demonstrated that mode of administration and efficacy had the greatest impact on preferences, with a relative importance of 40.5% and 30.6%, respectively. In a direct comparison of vaccine profiles representing the efficacy, side effects, and other characteristics of LAIV and TIV, 79% of children preferred the LAIV-like profile.Conclusion: Children in the sample had consistent opinions regarding influenza vaccine attributes and consider vaccine efficacy and mode of administration to be important. Children can be informed participants in influenza prevention and can be included in discussions regarding influenza vaccination
机译：背景：虽然每年接种流感疫苗是由CDC为儿童6个月及旧的建议，接种率仍然不理想。对于健康，美国2岁及以上的美国儿童，流感疫苗可分别作为肌肉注射（TIV）或鼻内喷雾（Laiv）。关于儿童的经验和偏好对流感疫苗属性的偏好而言。目的：检查流感疫苗属性的偏好及其在儿童之间的相对重要性。方法：向8-12岁的儿童施用于从站在网上取样的儿童进行管理美国人口的小组代表。通过年龄，性别和父母的流感疫苗接种行为来分层儿童。该调查包括确定儿童对流感疫苗属性的偏好的问题，包括疗效，常见副作用的机会和行政模式。它包括联合（权衡）问题，其中儿童在两种流感疫苗之间进行不同的属性，具有不同的特征。我们还调查了儿童的理解和完成联合问题的能力。结果：544名儿童完成了调查（响应率37％）。儿童最常选择的疗效是最重要的疫苗属性，然后分别为给药方式（分别为45％和31％）。当要求他们偏好接受流感疫苗作为“射击”或“鼻子喷雾”时，大多数（69％）优选鼻喷雾。对儿童完成联合调查的能力评估表明，85％的样本能够完成联合任务。与联合反应的分析表明，给药和疗效模式对偏好产生最大的影响，分别具有40.5％和30.6％的相对重要性。在表示功效的疫苗型材，副作用，LAIV和TIV等特点的直接比较，儿童的79％首选减毒活疫苗样profile.Conclusion：儿童样本中有关于流感疫苗的属性一致的意见，并考虑疫苗的有效性和行政方式很重要。儿童可以在流感预防方面通知参与者，并可以包含在有关流感疫苗接种的讨论中

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